Publications by authors named "Pang Wen-Hui"
Six new prenylated flavonoids, named visconaeas A-F (1-6), and eleven known isopentenyl flavonoids (7-17) were isolated from Dodonaea viscosa (L.) Jacq. The structures of the separated compounds were determined through comprehensive spectral analysis and quantum chemical calculations.
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- Researchers isolated 15 new prenylated coumarins (called asiaticasics A-O) from the ethyl acetate fraction of Toddalia asiatica, along with 9 known derivatives.
- The structures of these new compounds were confirmed using spectroscopic analysis and reference data.
- Biological tests showed compounds 3 and 12 exhibited anti-inflammatory effects, with compound 12 reducing pyroptosis in J774A.1 cells by inhibiting the NLRP3 inflammasome, supported by both biochemical and morphological evidence.
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- - Four new diterpenoids (1-4) and sixteen known ones (5-20) were extracted from the plant Euphorbia helioscopia L., with compounds 1 and 2 categorized as rhamofolane, compound 3 as lathyranes, and compound 4 as jathophanes.
- - The isolated compounds were evaluated for their cytotoxicity and efficacy against the Zika virus, with compounds 9 and 15 demonstrating low cytotoxicity and high anti-Zika activity (EC values of 2.63 and 5.94 μM, respectively).
- - Researchers further assessed the inhibitory effects of these compounds on protein levels using techniques like Western blotting and immunof
Three new lanostane triterpenoids () along with two new amides fatty compounds () were isolated from the ethyl acetate extract of a culture of the endophytic fungus gx-2. Their structures were identified by 1D and 2D NMR spectral data and HRESIMS. Compounds were evaluated for their anti-inflammatory and tyrosinase inhibition activities.
View Article and Find Full Text PDFTwo new compounds, including a norsesquiterpenoid, annuionone H (), and a quassinoid, picraqualide G (), along with eleven known compounds (), were isolated from the twigs and leaves of . Comprehensive spectroscopic analyses and NMR calculation with DP4+ analysis were used to identify their structures. Moreover, of all these compounds, compound showed a week inhibition rate in the anti-inflammatory screening results against mouse macrophage J774A.
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- A new alkaloid named picrasine A and two new quassinoids called picralactones A and B were discovered in the plant Picrasma chinensis P.Y. Chen, along with eleven known compounds.
- The structures of these compounds were identified using advanced techniques like NMR, HR-ESI-MS, and IR spectroscopy, along with comparisons to existing literature.
- Although some of the compounds were tested for their ability to inhibit tyrosinase, none showed significant inhibitory effects.
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- * Their structures were determined using advanced spectroscopic data and methods like DP4+ analysis for relative configurations and quantum chemical calculations for absolute configurations.
- * Certain compounds (1, 3, 5, 9, 10, 12, 15, 16, and 19) exhibited significant inhibitory effects on NLRP3 inflammasome activation, and compound 10 specifically reduced IL-1β secretion and blocked macrophage pyroptosis in lab tests.
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- Two new clerodane norditerpenoids, named Callintegers A and B, were discovered featuring a unique 6/6/6-fused tricyclic ring system.
- Their structures and configurations were confirmed using advanced techniques like quantum chemical calculations and X-ray diffraction.
- Compound B was found to inhibit IL-1β secretion effectively, suggesting it disrupts NLRP3 inflammasome activation, with a notable IC value of 5.5 ± 3.2 μM.
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- The rising interest in secondary metabolites due to their effects on fruit quality, plant growth, and human health has spurred the development of advanced analytical techniques.
- A new UHPLC-QqQ-MS/MS method was created to quickly and accurately detect and measure 47 metabolites, including various isomers, in just 13 minutes.
- This method demonstrated high precision and low detection limits, and it was successfully used to analyze different parts of pummelo fruit from two varieties.
[Regulation of microbial infection to the airway allergic disease].
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
November 2012
Article Synopsis
- The study investigates the clinical features and recurrence rates of sinonasal inverted papilloma (NIP), assessing factors contributing to recurrence and comparing surgical methods.
- Among 156 patients, recurrence occurred in 19 cases, with some progressing to squamous cell carcinoma, showing a slight variation in recurrence rates among different surgical approaches but no significant statistical differences.
- The results suggest that thorough initial surgical removal is crucial for reducing recurrence, while the Krouse classification stage and type of surgery were less influential on outcomes.