Targeting ninjurin 2 by miR-764 regulates hydrogen peroxide (HO)-induced neuronal cell death.

Ninjurin 2 (NINJ2) is a novel adhesion molecule expressed in neurons and glial cells. The current study determined if specific microRNA (miRNA) can regulate NINJ2 expression in human neuronal cells. Sequence analysis of NINJ2 mRNA 3'-untranslated region (3'-UTR) revealed that microRNA-764 (miR-764) putatively targets NINJ2.

Synaptic Ultrastructure Might Be Involved in HCN-Related BDNF mRNA in Withdrawal-Anxiety After Ethanol Dependence.

Withdrawal from ethanol dependence has been associated with heightened anxiety and reduced expression of Brain-derived neurotropic factor which promotes the synaptic transmission and plasticity of synapses. Hyperpolarization-activated cyclic nucleotide-gated channel 1 regulates expression; however, whether Hyperpolarization-activated cyclic nucleotide-gated channel 1-related Brain-derived neurotropic factor is involved in the synaptic ultrastructure that generates withdrawal-anxiety has been poorly perceived. Sprague-Dawley rats were treated with ethanol 3-9% (v/v) for a period of 21 days.