The Application of Traditional Chinese Medicine-Derived Formulations in Cancer Immunotherapy: A Review.

Background: Cancer immunotherapy is an advanced therapeutic approach that harnesses the body's immune system to target and eliminate tumor cells. Traditional Chinese medicine (TCM), with a history rooted in centuries of clinical practice, plays a crucial role in enhancing immune responses, alleviating cancer-related symptoms, and reducing the risks of infections and complications in cancer patients.

Methodology: This review systematically examines the current literature on TCM-based formulations in cancer immunotherapy.

Gradient experiment reveals physiological stress from heavy metal zinc on the economically valuable seaweed Sargassum fusiforme.

Zn is a common heavy metal pollutant in water bodies and accounts for the largest proportion of heavy metal pollutants in many rivers entering the sea. This study investigated the growth and physiological response characteristics of Sargassum fusiforme under different divalent Zn ion concentration gradients. We observed that low concentration Zn treatment (<2 mg L) exerted no significant effect on the growth rate, photosynthesis, and nitrogen metabolism-related indicators of S.

Automatic Optical Path Alignment Method for Optical Biological Microscope.

A high-quality optical path alignment is essential for achieving superior image quality in optical biological microscope (OBM) systems. The traditional automatic alignment methods for OBMs rely heavily on complex masker-detection techniques. This paper introduces an innovative, image-sensor-based optical path alignment approach designed for low-power objective (specifically 4×) automatic OBMs.

Preoperatively predicting human epidermal growth factor receptor 2-low expression in breast cancer using neural network model based on multiparameter magnetic resonance imaging.

Background: Preoperative prediction of human epidermal growth factor receptor 2 (HER2)-low expression using magnetic resonance imaging (MRI) can enhance the selection of clinical treatment strategies and enhance patient outcomes. Herein, we investigated the value of a neural network model constructed with multiparametric MRI in diagnosing HER2-low breast cancer.

Methods: This retrospective study involved two different centers.

The microRNA-29ab1/Zfp36/AR Axis in the Hypothalamus Regulates Male-Typical Behaviors in Mice.

Male-typical behaviors such as aggression and mating, which reflect sexual libido in male mice, are regulated by the hypothalamus, a crucial part of the nervous system. Previous studies have demonstrated that microRNAs (miRNAs), especially , play a vital role in reproduction and the neural control of behaviors. However, it remains unclear whether affects reproduction through the hypothalamus-mediated regulation of male-typical behaviors.

A segmentation-combination data augmentation strategy and dual attention mechanism for accurate Chinese herbal medicine microscopic identification.

Introduction: Chinese Herbal Medicine (CHM), with its deep-rooted history and increasing global recognition, encounters significant challenges in automation for microscopic identification. These challenges stem from limitations in traditional microscopic methods, scarcity of publicly accessible datasets, imbalanced class distributions, and issues with small, unevenly distributed, incomplete, or blurred features in microscopic images.

Methods: To address these challenges, this study proposes a novel deep learning-based approach for Chinese Herbal Medicine Microscopic Identification (CHMMI).

Impacts of zein-fucoidan nanoparticles with and without curcumin on gel properties of golden threadfin bream (Nemipterus virgatus) surimi.

Zein-fucoidan nanoparticles (ZFNPs) as an excellent colloidal delivery system for bioactive compounds, such as curcumin (CUR), show a great application potential in the food industry. Herein, various amount of ZFNPs, ZFNPs loaded with CUR (CZFNPs) and free CUR were added into golden threadfin bream (Nemipterus virgatus) surimi to explore their impacts on the gel properties. Dynamic rheological tests showed that storage modulus (G') and loss modulus (G") of surimi gels with the additive amount of ZFNPs and CZFNPs under 0.

A network coding transmission strategy for preventing eavesdropping attacks.

For secure network coding to prevent eavesdropping attacks, a general design is used that puts restrictions on the eavesdropping channel set or encryption technology is embedded, which can cause problems in practical applications. Based on random linear network coding technology, in this paper, a transmission strategy to prevent eavesdropping attacks is proposed for single-source multicast networks, without either precondition of restricting the eavesdropping channel set or embedding encryption technology. The data transmission process is divided into three phases, and the global encoding vectors are separated from the encoded data on the channel.

Optimized irrigation practices with fertilizer utilization strategies to improve photo-fluorescence efficiency, vascular bundles and maize production in semi-arid regions.

The mechanism of irrigation models combined with fertilizer utilization strategies under the biodegradable film mulching could greatly promote crop photosynthesis, vascular bundles structure; resource utilization and maize production are unclear in semi-arid areas. Unfortunately, this mechanism provides a scientific basis for improving irrigation and fertilizer utilization. A field study was carried out during 2021-2022 years.

A review of human cornea finite element modeling: geometry modeling, constitutive modeling, and outlooks.

The cornea is a vital tissue of the human body. The health status of the cornea has a great impact on the quality life of person. There has been a great deal of research on the human cornea biomechancis.

Mechanisms of Xuefu Zhuyu Tang in the Treatment of Diabetic Erectile Dysfunction in Rats Through the Regulation of Vascular Endothelial Function by CaSR/PLC/PKC and MEK/ERK/RSK Pathways.

Xuefu zhuyu Tang (XFZYT) is a classic formula used for promoting blood circulation and resolving blood stasis in Traditional Chinese Medicine. Clinical data have indicated that XFZYT plays a significant therapeutic role in diabetes-induced erectile dysfunction (DIED) disease, but the underlying mechanism remains elusive. Male Sprague-Dawley (SD) rats were randomly categorized into normal, model, and treatment groups.

A deep-learning system for diagnosing ectopic eruption.

Objectives: To construct a diagnostic model for mixed dentition using a multistage deep-learning network to predict potential ectopic eruption in permanent teeth by integrating dentition segmentation into the process of automatic classification of dental development stages.

Methods: A database was established by reviewing 1576 anonymous panoramic radiographs of children aged 6-12 years, collected at the Stomatology Hospital, Zhejiang University School of Medicine. These radiographs were categorised as normal or ectopic eruption, with expert diagnoses serving as a benchmark for training and evaluating artificial intelligence (AI) models.

Does the integration of digital and real economies promote urban green total factor productivity? Evidence from China.

Enhancing urban green total factor productivity (UGTFP) is of great significance in driving the green transformation of cities. The integration of the digital economy and real economy (IDR) offers a novel approach to improving UGTFP. This paper constructs a theoretical analytical framework to examine the impact of IDR on UGTFP.

Simultaneous determination of pesticides, mycotoxins and ferulic acid in Angelica sinensis by GC/LC-Q-TOF/MS.

In this study, a strong applicable method that could determine a total of 33 pesticides (54 compounds), 11 mycotoxins and functional components (ferulic acid) simultaneously in Angelica sinensis was developed. The compatibility of the sample pretreatment method for pesticides, mycotoxins, and functional components was improved by optimizing the acidity of extraction solvents, the sequence of ice bath and oscillation, the volumetric solution, and so on. The PRiME HLB SPE pretreatment method was chosen as the optimal one when comparing four pretreatment methods.

Effect of Near-Freezing Storage Combined with High-Voltage Electric Fields on the Freshness of Large Yellow Croaker.

Seafood is highly perishable after being caught, making effective preservation technology essential. A few studies have explored the mechanisms of near-freezing storage combined with high-voltage electric fields for seafood preservation. This study uses near-freezing storage at -1 °C in conjunction with three high-voltage electric fields (5 kV/m, 8 kV/m, and 16 kV/m) to store large yellow croakers for 21 days and assesses their quality through sensory evaluation, pH values, malondialdehyde, total volatile basic nitrogen, and total viable counts.

Stereotactic Radiation Therapy for Localized Prostate Cancer: 10-Year Outcomes From Three Prospective Trials.

Purpose: SABR is growingly accepted for the treatment of localized prostate cancer with recent randomized trials showing noninferiority compared with conventional or moderately hypofractionated radiation therapy. The natural history of prostate cancer necessitates extended surveillance for recurrence; however, there are a few prospective studies reporting long-term outcomes.

Methods And Materials: This study included patients with low- and intermediate-risk localized prostate cancer from 3 Canadian clinical trials enrolled from 2006 to 2013.

Family history and genetic risk score combined to guide cancer risk stratification: A prospective cohort study.

Family history (FH) of cancer and polygenic risk scores (PRS) are pivotal for cancer risk assessment, yet their combined impact remains unclear. Participants in the UK Biobank (UKB) were recruited between 2006 and 2010, with complete follow-up data updated until February 2020 for Scotland and January 2021 for England and Wales. Using UKB data (N = 442,399), we constructed PRS and incidence-weighted overall cancer PRS (CPRS).

Harnessing collective structure knowledge in data augmentation for graph neural networks.

Graph neural networks (GNNs) have achieved state-of-the-art performance in graph representation learning. Message passing neural networks, which learn representations through recursively aggregating information from each node and its neighbors, are among the most commonly-used GNNs. However, a wealth of structural information of individual nodes and full graphs is often ignored in such process, which restricts the expressive power of GNNs.

Deep-learning-based method for the segmentation of ureter and renal pelvis on non-enhanced CT scans.

This study aimed to develop a deep-learning (DL) based method for three-dimensional (3D) segmentation of the upper urinary tract (UUT), including ureter and renal pelvis, on non-enhanced computed tomography (NECT) scans. A total of 150 NECT scans with normal appearance of the left UUT were chosen for this study. The dataset was divided into training (n = 130) and validation sets (n = 20).

Subway Fine Particles (PM )-Induced Pro-Inflammatory Response Triggers Airway Epithelial Barrier Damage Through the TLRs/NF-κB-Dependent Pathway In Vitro.

Subways are widely used in major cities around the world, and subway fine particulate matter (PM) is the main source of daily PM exposure for urban residents. Exposure to subway PM leads to acute inflammatory damage in humans, which has been confirmed in mouse in vivo studies. However, the concrete mechanism by which subway PM causes airway damage remains obscure.