Ultrasound-Guided vs Non-Ultrasound-Guided Angio-Seal Vascular Hemosasis After Endovascular Treatment for Peripheral Artery Disease: An Observational Study.

Ultrasound visualization of vascular closure devices during endovascular access closure leads to a significant decrease in overall and major post interventional access site complications. This non-invasive and often readily available imaging technique could therefore lead to an important decrease in morbidity and subsequent overall health care costs when added to the standard intervention protocol. With the increasing use of endovascular techniques to treat peripheral artery disease, the addition of ultrasound-techniques in closure of endovascular access sites could potentially have a large clinical impact, both on patient outcomes as well as financial outcomes.

Emergency embolization of a massive life-threatening placenta percreta bleeding following delivery by Cesarean section.

The rise in the number of Cesarean sections (CS) worldwide has increased the incidence of the placenta accreta spectrum disorders in the past years. About 5% of patients undergoing a CS develop placenta percreta. A 30-year-old woman, G2P1 with previous uncomplicated CS delivery had an elective CS delivery at 37w6d.

Solvation force and adsorption isotherm of a fluid mixture in nanopores of complex geometry based on fundamental measure theory.

A novel method based on the fundamental measure theory is developed to calculate the solvation force and adsorption isotherm of a Lennard-Jones fluid mixture in complex geometries. Fast Fourier transform and 3D-voxel discretization are used for accurately computing the confined fluid densities in a closed pore of arbitrary geometry. Given the fluid densities, the solvation force distribution at the solid surface can be calculated using a new formulation from either mechanical or thermodynamic approach.

Ultra-small superparamagnetic iron oxides for metastatic lymph node detection: back on the block.

In the past 15 years, encouraging clinical results for the detection of small lymph node metastases was obtained by the use of Combidex-enhanced MRI (CEM, also known as magnetic resonance lymphography). Withdrawal of the European Medicines Agency approval application by the manufacturer made it impossible for patients to benefit from this agent; a loss, especially for men with prostate cancer. Current conventional imaging techniques are not as accurate as CEM is, thus a surgical diagnostic exploration (extended lymph node dissection) is still the preferred technique to evaluate the lymph nodes, resulting in peri- and postoperative complications.

Clinical study using adipose-derived mesenchymal-like stem cells in acute myocardial infarction and heart failure.

Adipose tissue represents an abundant, accessible source of regenerative cells that can be easily obtained in sufficient amount for therapy. Adipose-derived regenerative cells (ADRC) are comprised of leukocytes, smooth muscles, endothelial cells, and mesenchymal stem cells. In contrast to bone-marrow-derived MSC, the abundance of adipose tissue in patients and the higher frequency per unit mass of regenerative cells allow for the isolation of cells in therapeutic meaningful amounts in less than 2h after donor tissue acquisition.

Ventricular fibrillation frequency from implanted cardioverter defibrillator devices.

Aims: The dominant frequency (DF) of ventricular fibrillation (VF) provides a measure of cycle length that may relate to the underlying complexity of the arrhythmia. Dominant frequency analysis may therefore provide insights into VF mechanisms, and potentially guide future therapies. Dominant frequency analysis can be undertaken on stored electrograms (EGMs) from implanted cardioverter defibrillator devices (ICDs).

[Cellular and humoral immunity indices in patients with myocardial infarct complicated by thromboendocarditis].

Data are submitted on the time course of immunologic indices in 50 patients with myocardial infarction (MI) presenting with complication-free course, and 58 patients with MI complicated by thromboendocarditis. Important changes were revealed in the immune status--both cellular and humoral--during the development of thrombosis of the left ventricle secondary to MI. The cellular immunity was characterized by a decline in the levels of T-lymphocytes, particularly those of T-suppressors, augmentation of B-lymphocytes.

[Pathogenesis of experimental peritonitis].

It was found that joint action of two independent factors is necessary for the development of peritonitis. They are: prolonged infection of the abdominal cavity and an inflammatory process caused by an extraperitoneal source. Investigations of the endogenous intoxication, system of regulation of the aggregate state of blood, immunity, esterase and antitrypsin activity in dynamics of the development of experimental peritonitis and septic shock were performed.

[Disorders in the hypophysis-adrenal and hypophysis-thyroid systems of patients with acute pneumonia and the ways for their therapeutic correction].

Using RIA, 188 patients with acute pneumonia were examined over time for the blood ACTH, cortisol, TTH, T3 and T4 content as well as for T4/T3, TTH/T3 and TTH/T4 correlations. Under discussion are causes, approaches to the prevention and correction of the hormonal disorders revealed in the pituitary-adrenal system in patients with an unfavourable course of pneumonia. The majority of the patients manifested thyroid hypofunction and TTH hypersecretion, which remained unchanged even during the clinical recovery, since the first days of the disease.

[Function of the kallikrein-kinin and prostaglandin systems of the kidneys in patients with chronic pyelonephritis].

The activity of the kallikrein-kinin, prostaglandin and cyclase systems was assessed in 117 patients with chronic pyelonephritis with and without arterial hypertension. Pyelonephritis is shown to be associated with a dysfunction of the pressor-depressor mechanisms examined, featuring a depression of vasodepressor reactions. Patients with normal, increased and depressed humoral parameters could be found in each study group, the changes being particularly marked in patients with chronic pyelonephritis, combined with arterial hypertension.

[Endocrine cells of the gastroduodenal area in duodenal ulcer].

A study has been carried out to substantiate the assumption that excessive proliferation of major gastroduodenal endocrine cells may be predetermined genetically. Hereditary predisposition to the hyperplasia of cells belonging to the APUD system may be inherited both through the male and female lines. Duodenal ulcers (DU) undoubtedly involves multifactorial inheritance.

[Quantitative characteristics of various endocrine cells of the duodenal bulb in the pre-ulcer conditions and duodenal ulcer].

Endocrine cells of the duodenal bulb producing adrenalin, noradrenalin, serotonin, histamine and beta-endorphine were assayed in 12 patients with preulcer and 39 patients with duodenal ulcer. It is shown that preulcer was mainly characterized by hyperplasia of endocrine cells in the duodenal bulb mucosa, secreting adrenalin and noradrenalin in the presence of the deficiency of beta-endorphine-producing cells. The recurrent duodenal ulcer was associated with a dramatic fall in the number of catecholamine-containing endocrine cells in the duodenal bulb.

[Clinical periodization of myocardial infarct].

Comparison of the clinical and laboratory tests with the findings of post-mortem examination of 82 hearts of patients who had died in different periods after the onset of the disease allowed the authors to distinguish three periods in the clinical course of myocardial infarction: necrotic, inflammatory and adaptational. Fever, leukocytosis, the time course of MB CPK activity, and the results of polyelectrode ECG are reliable indicators of the duration of the necrotic period. The content of the protein-carbohydrate complexes in the blood adequately reflect the exudative-proliferative phase, while the content of collagen metabolites in blood and urine reflect the collagenization phase of the inflammatory period.

[Kallikrein-kinin system of the kidneys and blood in hypertension and chronic pyelonephritis].

Comparative study of the renal and blood kinin system in patients with hypertensive disease and in those with chronic pyelonephritis revealed its different reaction to a similar character of arterial pressure in these patients, which suggests that the kinin system differs in its significance in the pathogenesis of hypertension in these diseases. It is recommended to use the values of the renal and blood kinin system in practice for the differential-diagnostic purpose in the planned stage-by-stage examination of patients with arterial hypertension.