Polymorphism Dependent Cytotoxicity, Cellular Uptake, and Live Cell Imaging Studies on Napthalimide-Vinyl-Phenothiazine Conjugate.

Polymorphism-dependent cytotoxicity and cellular uptake of drug molecules have been studied for the past two decades. However, the visualization of polymorph-dependent cellular uptake and cytotoxicity using microscopy imaging techniques has not yet been reported. The luminescent polymorph is an ideal candidate to validate the above hypothesis.

Effect of the Molecular Conformation on Excitation Energy Transfer in Conformationally Constrained Boryl-BODIPY Dyads.

We studied the dual emission characteristics of a series of boryl-BODIPYs (-) comprised of triarylborane (TAB) as an energy donor and BODIPY as an energy acceptor. The molecular conformations of dyads - were systematically tuned by judiciously changing the spacer that bridged the boryl and BODIPY moieties. Frontier molecular orbitals (FMOs) are localized in , , and with a twisted molecular conformation.

Access to highly substituted oxazoles by the reaction of α-azidochalcone with potassium thiocyanate.

The reactivity of α-azidochalcones has been explored for the preparation of highly substituted oxazoles via a 2-azirine intermediate. The azidochalcones, when treated with potassium thiocyanate in the presence of potassium persulfate, lead to 2,4,5-trisubstituted oxazoles in good yields. Incidentally, 2-aminothiazoles are the products when ferric nitrate is employed instead of persulfate in the above reaction.

Delayed Fluorescence, Room Temperature Phosphorescence, and Mechanofluorochromic Naphthalimides: Differential Imaging of Normoxia and Hypoxia Live Cancer Cells.

We study the effect of molecular conformation on the electronic coupling between the donor amines and acceptor 1,8-naphthalimide (NPI) in a series of D-A systems - (A = NPI; D = phenothiazine, phenoxazine, carbazole, diphenylamine, respectively, for , , , and ). Weakly coupled systems show dual emission in the solution state, while strongly coupled systems show single emission bands. The energy of transitions and photoluminescence (PL) quantum yield are sensitive to the molecular conformation and donor strength.