Publications by authors named "Pandey Shivani"
Aim: To evaluate the efficacy of sesame oil-pulling in periodontitis with/without Type2 Diabetes Mellitus (T2DM), compared to Chlorhexidine, for its oral and systemic health benefits.
Material And Methods: Total of 120 periodontitis patients, without (Group A; 60)/with (Group B; 60) T2DM, underwent control (chlorhexidine 0.12%; Group A1 & B1) and test (sesame oil-pulling; Group A2 & B2) interventions.
Bacopaside-I ameliorates motor dysfunction and neurodegeneration in rat model of Parkinson's disease.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Article Synopsis
- Chronic administration of Bacopa monnieri extract shows potential neuroprotective effects in animal models of neurodegenerative disorders, including Parkinson's and Alzheimer's diseases.
- The study specifically tested Bacopaside-I (BS-I), highlighting its ability to improve motor function and reverse dopamine depletion caused by rotenone, a chemical used to induce Parkinson's-like symptoms in rats.
- Findings suggest that BS-I increases key genetic markers and the number of dopamine-producing neurons, establishing its potential as a basis for future drug development against Parkinson’s disease.
Aims: Diabetes associated cognitive decline (DACD) is a common CNS-related consequence of diabetes. The primary clinical manifestation of DACD includes learning and memory impairment. Unfortunately, there is no cure to delay the cognitive symptoms of diabetes.
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- Emotional engagement during trauma recall is crucial in trauma-focused therapy, particularly in Cognitive Processing Therapy (CPT) for PTSD.
- A study involving 142 women with PTSD found that lower heart rate (HR) reactivity during trauma recall was linked to less improvement in specific PTSD symptoms and higher rates of treatment dropout.
- The results indicate that lower HR reactivity could signal difficulties in treatment response, emphasizing the need for emotional activation in therapy, though further research is necessary to fully understand its effects.
Article Synopsis
- Prepulse inhibition (PPI) is a process that helps filter out weak sensory stimuli, and previous research indicates that smoking withdrawal can negatively affect this filtering, especially in individuals with mental health issues.
- In a study involving trauma-exposed individuals, researchers assessed how changes in PPI during smoking cessation corresponded to smoking abstinence, finding that those who maintained abstinence showed higher PPI levels.
- The results suggest that improving PPI during the early stages of quitting smoking could support better cessation outcomes for people with a history of trauma, particularly those at greater risk for tobacco addiction.
Berberine ameliorates glucocorticoid-induced hyperglycemia: an in vitro and in vivo study.
Naunyn Schmiedebergs Arch Pharmacol
March 2024
Berberine (BBR), a bioactive compound isolated from Coptidis Rhizoma, possesses diverse pharmacological activities including anti-bacterial, anti-inflammatory, antitumor, hypolipidemic, and anti-diabetic. However, its role as an anti-diabetic agent in animal models of dexamethasone (Dex)-induced diabetes remains unknown. Studies have shown that natural compounds including aloe, caper, cinnamon, cocoa, green and black tea, and turmeric can be used for treating Type 2 diabetes mellitus (DM).
View Article and Find Full Text PDFDiabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia. DM can lead to a number of secondary complications affecting multiple organs in the body including the eyes, kidney, heart, and brain. The most common effect of hyperglycemia on the brain is cognitive decline.
View Article and Find Full Text PDFPseudogenes in Juvenile Nasopharyngeal Angiofibroma: First Pilot Observation.
Indian J Otolaryngol Head Neck Surg
October 2022
Article Synopsis
- The study examines the role of pseudogenes (PG) in juvenile nasopharyngeal angiofibroma (JNA), previously deemed non-functional "junk" DNA, by analyzing fresh JNA samples for molecular expressions of specific PG and their parent genes.
- Key findings indicate that certain pseudogenes (like VEGFR1P1, PDGFAP1, and IL6RP1) were highly expressed, while others (like POU5F1B and FGFR3P1) showed reduced expression, with significant differences noted particularly between IL6R and IL6RP1.
- Although the study suggests a notable role of pseudogenes in JNA, no clinical
Article Synopsis
- Many post-9/11 veterans experience negative mental health symptoms, like PTSD and depression, which adversely affect their physical health and overall functioning.
- The study analyzed 1032 veterans over about 7 years, using gender-specific methods to explore how mental and physical health influence each other over time.
- Results indicated that PTSD is linked to poorer physical health, with women showing a reciprocal relationship, while depression symptoms also worsen physical health, highlighting the need for integrated mental and physical healthcare for veterans.
Genistein (GE) or 4',5,7-trihydroxyflavone, a plant derived isoflavone, is a biologically active compound having several beneficial properties. Studies showed that GE possesses anti-neoplastic, anti-tumor, anti-helminthic, anti-oxidant, and anti-inflammatory activities. Herein, we investigated the neuroprotective effects of GE in a mouse model of hypoxia-induced amnesia.
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- The study examined the prevalence and characteristics of portopulmonary hypertension in patients with hepatic cirrhosis, finding a prevalence rate of 9.3%.
- Patients with portopulmonary hypertension had significantly lower hemoglobin levels and exhibited dilation in the right atrial and ventricular areas compared to those without the condition.
- Various echocardiographic measurements, including right ventricular systolic pressure and pulmonary artery diameter, were significantly higher in patients with portopulmonary hypertension, indicating potential clinical associations.
Parkinson's disease (PD) is the second most common devastating neurodegenerative disorder. Presently used therapies for PD have severe side effects and are limited to only temporary improvement. Therefore, a new therapeutic approach to treat PD urgently needs to be developed.
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- - This clinical trial tested a probiotic's effectiveness combined with scaling and root planing (SRP) for treating chronic periodontitis in 48 patients, divided into three groups receiving different treatments: placebo, single probiotic application, and incremental probiotic applications.
- - Results showed all groups experienced improvement in probing pocket depth and clinical attachment after 24 weeks, but the incremental probiotic group had significantly better localized plaque and gingival scores compared to the placebo group.
- - The study concluded that using the probiotic incrementally alongside SRP can enhance the treatment outcomes for chronic periodontitis, suggesting it as a beneficial addition to non-surgical treatment approaches.
Article Synopsis
- Asthma is influenced by genetic factors, particularly vitamin D and its receptor gene variations, but the exact inflammatory processes related to these variations are not fully understood.
- The study aimed to explore the link between specific gene polymorphisms and asthma by comparing children with asthma symptoms to those with central nervous system disorders but no respiratory issues.
- Results showed that children with a certain gene variant (heterozygous AC genotype) had a significantly higher risk of developing asthma, indicating a potential genetic predisposition.
Role of gene polymorphisms with community acquired pneumonia in North Indian children: a case-control study.
Int J Mol Epidemiol Genet
February 2021
Article Synopsis
- Community-acquired pneumonia (CAP) is a significant cause of mortality in children under five, and the vitamin D receptor gene is linked to how the body responds to infections, influencing CAP outcomes.
- This study aimed to explore the connection between specific gene polymorphisms and the incidence of CAP in children aged 2-59 months, involving 160 hospitalized cases and 160 healthy controls.
- The findings indicated that certain genotypes of the vitamin D receptor gene were associated with an increased risk of developing CAP among Indian children.
Parkinson's disease (PD) is characterized by progressive death of dopaminergic neurons. The presently used medicines only tackle the symptoms of PD, but none makes a dent on the processes that underpin the disease's development. Herbal medicines have attracted considerable attention in recent years.
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- Genistein (GE) is a natural compound with various health benefits, including anti-cancer and anti-inflammatory properties, but its effects on cognitive function have not been thoroughly researched.
- This study explored GE's potential to combat memory loss in mice exposed to a low-oxygen environment (hypoxia) over 28 days, using specific behavioral tests to assess cognitive impairment.
- Results indicated that GE improved cognitive function by reducing oxidative stress and inflammation in the brain while boosting the expression of neuroprotective genes, suggesting it may be a promising treatment for amnesia-related conditions.
Article Synopsis
- Parkinson's Disease (PD) involves increased oxidative stress and diminished dopamine levels, making current treatments have undesirable side effects; thus, a new bioinspired molecule is needed.
- The study focuses on a complex of camel α-lactalbumin (α-LA) and oleic acid (CLOA) as a potential neuroprotective agent, showing that altering α-LA enhances its effectiveness when combined with oleic acid.
- Experimental results reveal that the CLOA complex helps reduce oxidative stress and increases cell viability by boosting dopamine levels and certain protein expressions, suggesting it could be a promising candidate for future PD therapies.
Article Synopsis
- Parkinson's disease (PD) is a neurodegenerative disorder marked by the loss of dopamine-producing neurons and buildup of α-synuclein in the brain, linked to neuroinflammation.
- Research showed that Bacopa monnieri (BM) can reduce inflammation in PD by lowering pro-inflammatory cytokines, α-synuclein levels, and reactive oxygen species in an animal model.
- Pre-treatment with BM proved more effective than co- or post-treatment, indicating its potential as a novel therapeutic option for various central nervous system disorders.
Otological and Visual Implications of Diabetes Mellitus in North Indian Population.
Indian J Otolaryngol Head Neck Surg
November 2019
The worldwide population of diabetic patients is increasing alarmingly with India claiming number one position. It causes irreversible damage to cochlear hair cells, vestibular apparatus, visual pathway, nephrons, nerves, if not checked in time. A total of 188 patients of diabetes mellitus were included in this prospective study.
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- * The study aimed to measure levels of malondialdehyde (MDA) and the defense enzymes superoxide dismutase (SOD) and catalase in the blood and cerebro-spinal fluid (CSF) of patients with these diseases to explore correlations with clinical factors.
- * Results showed significantly higher MDA levels in both CSF and blood of patients compared to controls, while catalase activity was higher and SOD activity was lower in patients; this suggests that these free radical parameters may serve as potential
Article Synopsis
- Parkinson's disease (PD) is a neurodegenerative disorder characterized by symptoms like rigidity and tremors, and a study explored the neuroprotective effects of Bacopa monnieri (BM) in a Parkinsonian mouse model induced by MPTP.
- Treatment with ethanolic extract of BM significantly improved motor functions and various biochemical parameters, such as enhancing dopamine levels and reducing oxidative stress indicators.
- BM also promoted a protective environment by reducing proteins associated with apoptosis and increasing anti-apoptotic proteins, suggesting it may guard dopaminergic neurons in PD by addressing oxidative stress and cell death pathways.
Article Synopsis
- Parkinson's disease (PD) is a common neurodegenerative disorder affecting older people, with research exploring herbal treatments as potential cures.
- In a study using a mouse model of PD, estrogen was tested alongside Levodopa (LD) to evaluate their effects on cognitive and motor recovery.
- Results showed that estrogen outperformed Levodopa in restoring dopamine neurons and improving various behavioral and biochemical markers in the brain, indicating its potential as a more effective treatment for PD.