Incremental Role of Cardiac CT Angiography in the Assessment of Left Ventricular Diastolic Function in Patients With Suspected Coronary Artery Disease With Normal Ejection Fraction: A Comparison With Transthoracic Echocardiography.

Objective: Diastolic dysfunction (DD) is defined as impaired left ventricular (LV) relaxation, caused by structural or functional heart diseases. We sought to assess the role of cardiac CT angiography (CCTA) as a tool to evaluate LV DD in patients with normal EF using the diastolic expansion index (DEI), as compared to transthoracic echocardiography (TTE) as the gold standard.

Methods: Patients presenting with atypical chest pain with suspected coronary artery disease (CAD) and having a normal LV ejection fraction on TTE underwent CCTA using a dual source CT scanner.

Clarifying the Cardiovascular Morphology and Associated Abnormalities in Patients with Double Inlet Right Ventricle Using Multidetector CT Angiography.

We sought to evaluate the intracardiac morphology and associated cardiovascular anomalies in patients with double inlet right ventricle (DIRV) on multidetector CT angiography. A retrospective search of our departmental database was conducted from January 2014 to January 2023 to identify patients with a diagnosis of DIRV on CT angiography. The intracardiac anatomy and associated cardiovascular abnormalities were systematically evaluated.

Isolation of left brachiocephalic artery in a patient with tetralogy of Fallot.

We present the case of a 4-year-old girl with tetralogy of Fallot associated with an incidentally detected isolation of the left brachiocephalic artery, with no communication between it and the pulmonary artery or ductus arteriosus. The case highlights the unusual association and hemodynamic consequences of the condition.

Evaluation of reliability and radiation dose reduction in coronary artery calcium scoring by using a low tube current and low kilo-voltage peak with advanced modelled iterative reconstruction.

Objective: The present study sought to compare the reliability and radiation dose of coronary artery calcium (CAC) scoring using low tube current (16 mAs), low kilo-voltage peak (100 kVp) and advanced modelled iterative reconstruction (ADMIRE 5) with the standard protocol (80 mAs, 120 kVp, ADMIRE 3).

Material And Methods: A prospective single centre study including 200 consecutive patients with suspected coronary artery disease referred for CT coronary angiography was conducted. All 200 patients underwent CAC scoring using the low current-low kVp protocol as well as standard protocol and were subdivided into a derivation and validation cohorts.

Malignant metastatic melanoma in brain with unknown primary origin: a case report.

Introduction: Melanoma, a malignant tumor derived from neural crest melanocytes, predominantly affects the skin but can involve any organ with neural crest migration. Metastatic melanoma of unknown origin, particularly when it involves the brain, is associated with significant morbidity, mortality, and a typically poor prognosis.

Case Presentation: The authors present a 71-year-old man with a history of hypertension and seizure disorder who experienced a headache, transient loss of consciousness, and vomiting.

Acute Cortical Blindness Following Acute Carbon Monoxide Intoxication Due to Gas Geyser Syndrome.

Accidental carbon monoxide (CO) poisoning is common during the winters. The use of gas geysers by Indian households during this season for heating purposes may inadvertently lead to brain injury. Such cases can be misdiagnosed as seizures, resulting in inappropriate treatment.

Redesigning telemedicine: preliminary findings from an innovative assisted telemedicine healthcare model.

Background: Telemedicine holds immense potential to revolutionise healthcare delivery, particularly in resource-limited settings and for patients with chronic diseases. Despite proven benefits and policy reforms, the use of telemedicine remains low due to several patient, technology, and system-level barriers. Assisted telemedicine employs trained health professionals to connect patients with physicians, which can improve access and scope of telemedicine.

First report on exploration of structural features of natural compounds (NPACT database) for anti-breast cancer activity (MCF-7): QSAR-based virtual screening, molecular docking, ADMET, MD simulation, and DFT studies.

Unlabelled: Due to the high toxicity, poor efficacy and resistance associated with current anti-breast cancer drugs, there's growing interest in natural products (NPs) for their potential anti-cancer properties. Computational modelling of NPs to identify key structural features can aid in developing novel natural inhibitors. In this study, we developed statistically significant QSAR models based on NPs from the NPACT database, which have shown potential anticancer activity against the MCF-7 cancer cell lines.

Unicuspid unicommissural aortic valve.

We describe a case of a 30-year-old woman with gradually increasing dyspnoea on exertion where CT angiography revealed a unicuspid unicommissural morphology of the aortic valve. The present report highlights the anatomical and embryological aspects of this rare anatomical variant as well as the associated cardiovascular abnormalities.

Anthropometric Measurements of Foot in Undergraduate Medical Students of a Medical College: A Descriptive Cross-sectional Study.

Introduction: Anthropometry is one of the important parameters for differentiation of sex which varies significantly based on hereditary, geographical, racial, sexual, and other factors. This study was done to provide baseline foot anthropometric data for Nepali medical students to improve the accuracy of stature estimations and enhance forensic and clinical applications. The aim of the study was to calculate anthropometric measurements of foot in undergraduate medical students of a medical college.

Superficial CD34 Positive Fibroblastic Tumor: A Rare Entity With Cytological and Histopathological Correlation.

Superficial CD34-positive fibroblastic tumor (SPFT) is an extremely rare neoplasm of borderline (intermediate) category. To the best of our knowledge, less than 40 cases have been reported in the English literature. It is imperative to understand and emphasize its cytological features as fine needle aspiration cytology (FNAC) is still considered a first line of investigation in such cases in many countries including India.

Assessing the effect of therapeutic level of oxytetracycline dihydrate on pharmacokinetics and biosafety in Oncorhynchus mykiss (Walbaum, 1792).

The aim of the experiment was to investigate the pharmacokinetics of oxytetracycline dihydrate after a single oral administration of 80 mg kg day in rainbow trout and assess its biosafety at concentration of 80, 240, 400, and 800 mg kg day over 30 days, focusing on various aspects such as effective feed consumption, physiological responses, drug tolerance, and detection of low drug concentrations in rainbow trout. The pharmacokinetics study spanned a duration of 5 days, while the assessment of biosafety extended for a 30-day safety margin, followed by a subsequent 10-day residual analysis. Pharmacokinetic analysis revealed slow absorption with low-rate constant in tissues.

Fungi-derived Chitosan-CTAB composite-based electrode for electrochemical simultaneous detection of Cd (II) and Pb (II).

Organic polymers have found diverse applications in the industrial and scientific world. One such application is using chitosan-based electrochemical sensors, which have gained rapid popularity due to their unique properties. To further enhance the material's porosity and adsorption capacity, the incorporation of a surfactant into the film has been explored.

Inhibition of hepatic oxalate overproduction ameliorates metabolic dysfunction-associated steatohepatitis.

The incidence of metabolic dysfunction-associated steatohepatitis (MASH) is on the rise, and with limited pharmacological therapy available, identification of new metabolic targets is urgently needed. Oxalate is a terminal metabolite produced from glyoxylate by hepatic lactate dehydrogenase (LDHA). The liver-specific alanine-glyoxylate aminotransferase (AGXT) detoxifies glyoxylate, preventing oxalate accumulation.