Personalized medicine: An alternative for cancer treatment.

The incidence of cancer continues to increase worldwide, resulting in significant physical, emotional, and financial challenges for individuals, families, communities, and healthcare systems. Cancer is projected to be responsible for approximately 10 million deaths in 2020, accounting for one in six deaths globally. Prostate, colon, lung, and breast cancers are the most common types of cancer.

KMT2C Polymorphism in Familial Hypospadias.

Hypospadias, a common congenital anomaly of male genitalia, shows significant heritability and familial recurrence, particularly in consanguineous families. This study explored the role of KMT2C polymorphisms in a Yemeni family with two affected siblings. Comprehensive analysis identified 475 unique SNPs in KMT2C, with 59 shared between parents, suggesting common ancestry.

Neural correlates of auditory comprehension and integration of sanskrit verse: a functional MRI study.

In this investigation, we delve into the neural underpinnings of auditory processing of Sanskrit verse comprehension, an area not previously explored by neuroscientific research. Our study examines a diverse group of 44 bilingual individuals, including both proficient and non-proficient Sanskrit speakers, to uncover the intricate neural patterns involved in processing verses of this ancient language. Employing an integrated neuroimaging approach that combines functional connectivity-multivariate pattern analysis (fc-MVPA), voxel-based univariate analysis, seed-based connectivity analysis, and the use of sparse fMRI techniques to minimize the interference of scanner noise, we highlight the brain's adaptability and ability to integrate multiple types of information.

Quantifying the Diagnostic Utility of Baseline Testing in Concussion Management: An Analysis of Collegiate Athletes From the NCAA-DoD CARE Consortium Dataset.

Background: Although preseason baseline testing is a commonly recommended part of the concussion management process, its "value-added" contribution to the diagnosis of acute concussion compared with normative reference values remains in question.

Purpose: This research aimed to evaluate the diagnostic benefits of baseline testing in acute concussion assessment compared with normative reference values and characterize the athletes who receive the most diagnostic utility from baseline testing.

Study Design: Cohort study (Diagnosis); Level of evidence, 2.

Structural and functional analysis of rhizospheric bacterial diversity in the Pranmati basin, Himalayan critical zone observatory.

The study explores the structural and functional dynamics of rhizospheric bacterial diversity in the Pranmati basin, focusing on their ecological significance, diversity, and functional roles across dominant vegetation types; Rhododendron arboreum, Myrica esculenta, and Quercus leucotrichophora. The research provides critical insights into soil health and ecosystem functioning by analysing rhizospheric soil properties among the selected vegetations. The research findings reveal that Myrica esculenta exhibits the highest root colonization (95.

Epidemiological investigation of a cholera outbreak in Nepal-India border communities: Public health implications.

Objectives: On October 4, 2021, a cholera outbreak was reported in Kapilvastu District, one of Nepal's 26 districts bordering India. This study examined the outbreak's characteristics, response efforts, and the challenges faced.

Methods: A descriptive cross-sectional design was applied for the outbreak investigation.

Dengue dynamics in Nepal: A Caputo fractional model with optimal control strategies.

An infectious disease called dengue is a significant health concern nowadays. The dengue outbreak occurred with a single serotype all over Nepal in 2023. In the tropical and subtropical regions, dengue fever is a leading cause of sickness and death.

Enhancing systematic literature review adapting 'double diamond approach'.

Current literature review frameworks often lack quantification of literature volume, guidance on keyword inclusion, confidence in identifying knowledge gaps, and the formulation of research questions, which can lead to potential bias in research. This undermines the validity and reliability of reviews. In this paper, we aim to enhance the systematic literature review (SLR) methods-starting with a review of review literature followed by a review of empirical literature-to address these challenges.

Insights into Ecological Resettlements and Conservation-led Displacements: A Systematic Review.

A systematic literature review (SLR) on ecological resettlements and conservation-led displacements (hereafter 'ER') is essential for guiding future research and conservation strategies, yet it has not been conducted. We performed a comprehensive two-stage review-a review of reviews and a review of empirical articles from Web of Science and Scopus-using the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P). We extracted and analyzed data from 164 research articles, revealing three key themes in ER research: publication trends and geographical distribution, methodological approaches and data types, and thematic focus with associated governance and equity indicators.

FMR1 genetically interacts with DISC1 to regulate glutamatergic synaptogenesis.

Synaptic development and functions have been hypothesized as crucial mechanisms of diverse neuropsychiatric disorders. Studies in past years suggest that mutations in the fragile X mental retardation 1 (FMR1) are associated with diverse mental disorders including intellectual disability, autistic spectrum disorder, and schizophrenia. In this study, we have examined genetical interactions between a select set of risk factor genes using fruit flies to find that dfmr1, the Drosophila homolog of the human FMR1 gene, exhibits functional interactions with DISC1 in synaptic development.

Analysis of wrong blood in tube events at a hospital-based blood centre in a tertiary care referral hospital: A perspective from a lower middle-income country.

Background And Objectives: Wrong blood in tube (WBIT) continues to be a preventable cause of unintended harm to the patient. The literature describing extent of the problem, its consequences and factors leading to WBIT from the perspective of lower middle-income countries (LMICs) is limited. The present study describes WBIT and its outcome in a hospital-based blood centre from an LMIC.

The level of confidence of dentists in identifying intact and sectioned teeth.

Objective: This study aimed to assess the confidence levels of dentists in identifying intact and sectioned human teeth and to identify the factors contributing to variations in confidence levels.

Design: An anonymous Jisc e-survey showing 14 questions was sent to dentists worldwide. Apart from acquiring demographic details of the participants, ten three-dimensional (3D) tooth models were presented for tooth identification including the opinion on the level of confidence in identifying.

Neuroanatomical correlates of subjective tinnitus: insights from advanced cortical morphology analysis.

Subjective tinnitus, characterized by the perception of phantom sounds in the absence of external stimuli, presents significant challenges in both audiology and neurology. Once thought to primarily involve aberrant neural activity within auditory pathways, it is now understood to engage a broader array of neuroanatomical structures. This study investigated the connections between auditory, cognitive, and sensory processing regions, which are crucial for unraveling the complex neurobiological basis of tinnitus.

Bladder Adjuvant Radiation Therapy (BART): Acute and Late Toxicity From a Phase III Multicenter Randomized Controlled Trial.

Purpose: To report toxicity from the multicenter phase III randomized trial of Bladder Adjuvant Radiation Therapy (BART) after radical cystectomy and chemotherapy in high-risk muscle-invasive bladder cancer (MIBC).

Methods And Materials: Patients with nonmetastatic urothelial MIBC with ≥1 high-risk feature after radical cystectomy- pT3-4, pN1-3, nodal yield <10, positive margin, or ≥cT3 downstaged with neoadjuvant chemotherapy- were randomized 1:1 to observation (Obs) or adjuvant radiation therapy (RT) at 4 centers, stratified by pN stage (N0, N+) and chemotherapy (neoadjuvant, adjuvant, none). Stoma-sparing image guided intensity modulated RT 50.

Dental damage: Creating 3D anatomical models to illustrate destructive effects on human teeth.

Forensic odontologists often must identify human remains with damaged teeth. This damage is due to high-impact accidents, violence, or disasters. This 2-part study aimed to create two 3D digital models.

Topochemically synthesized NbVS as a stable anode for sodium-ion batteries.

Ternary metal sulfides having layered morphology are considered as potential active materials for various applications. Herein, NbVS is synthesized topochemically for the first time using a Nb-V-HDA complex having a lamellar structure by employing HS gas as the sulfidation agent. NbVS, as an anode for SIBs, exhibited a specific capacity of 101.

Positive identification through comparative dental analysis in mass disaster: a systematic review and meta-analysis.

Purpose: The study aimed to assess the probability of achieving positive identification through comparative dental analysis (CDA) and to determine the factors that influence its success rate in mass disaster scenarios.

Methods: An electronic literature search was conducted across six databases for observational studies that reported both the total number of mass disaster victims and the count of victims identified through CDA alone. A random-effect meta-analysis, using the proportion of victims identified with CDA as the effect size, was conducted alongside subgroup analyses based on the type of disaster (natural or non-natural), the disaster classification (open or closed), and the geographical region (i.

Multimodal boiling dataset with synchronized acoustic, optical, and thermal measurements under steady-state and transient heat loads.

Boiling is a high-performance heat dissipation process that is central to electronics cooling and power generation. However, there exists a practical limit of boiling heat transfer known as the critical heat flux (CHF), beyond which significant performance degradation is observed. Understanding the physical mechanism that triggers CHF is essential to meet the increasing cooling demands driven by power densification and device miniaturization.

Controlled Environment Ecosystem: A Cutting-Edge Technology in Speed Breeding.

The controlled environment ecosystem is a meticulously designed plant growing chamber utilized for cultivating biofortified crops and microgreens, addressing hidden hunger and malnutrition prevalent in the growing population. The integration of speed breeding within such controlled environments effectively eradicates morphological disruptions encountered in traditional breeding methods such as inbreeding depression, male sterility, self-incompatibility, embryo abortion, and other unsuccessful attempts. In contrast to the unpredictable climate conditions that often prolong breeding cycles to 10-15 years in traditional breeding and 4-5 years in transgenic breeding within open ecosystems, speed breeding techniques expedite the achievement of breeding objectives and F1-F6 generations within 2-3 years under controlled growing conditions.

Unlocking the tapestry of conservation: Navigating ecological resettlement policies in Nepal.

Conservation initiatives involve a complex interplay of various ecological, socio-political, and economic factors. Ecological resettlement (ER), implemented within the context of nature conservation policies, stands as one of the most contested issues worldwide. This study aims to navigate the domain of ER policy in conservation through discursive institutionalism and a policy arrangement approach.