Spectroscopic, quantum chemical, and topological calculations of the phenylephrine molecule using density functional theory.

In this work, Density Functional Theory (DFT) on Gaussian 09 W software was utilized to investigate the phenylephrine (PE) molecule (C9H13NO2). Firstly, the optimized structure of the PE molecule was obtained using B3LYP/6-311 + G (d, p) and CAM-B3LYP/6-311 + G (d, p) basis sets. The electron charge density is shown in Mulliken atomic charge as a bar chart and also as a color-filled map in Molecular Electrostatic Potential (MEP).

Genome-wide association study identifies key F-box genes linked to ethylene responsiveness and root growth in rice ( L.).

Rice ( L.) is a staple food for more than half of the world's population, but its yields are increasingly threatened by environmental problems, including soil compaction. This problem limits root growth which limits water and nutrient foraging capacity thus reduces productivity due to, restricted diffusion of ethylene, a key plant hormone playing an important role in exacerbating these effects.

LC-MS profiling and cytotoxic activity of Angiopteris helferiana against HepG2 cell line: Molecular insight to investigate anticancer agent.

Liver cancer is one of the most prevalent malignant diseases in humans and the second leading cause of cancer-related mortality globally. Angiopteris helferiana was mentioned as a possible anticancer herb according to ethnomedicinal applications. However, the molecular docking and chemical profiling of the bioactive phytoconstituents accountable for the reported anticancer action still require research.

Root RADAR: how 'rhizocrine' signals allow roots to detect and respond to their soil environment and stresses.

Agricultural intensification coupled with changing climate are causing soils to become increasingly vulnerable to stresses such as drought, soil erosion, and compaction. The mechanisms by which roots detect and respond to soil stresses remain poorly understood. Recent breakthroughs show that roots release volatile and soluble hormone signals into the surrounding soil, then monitor their levels to sense soil stresses.

Enhancing Crop Resilience: The Role of Plant Genetics, Transcription Factors, and Next-Generation Sequencing in Addressing Salt Stress.

Salt stress is a major abiotic stressor that limits plant growth, development, and agricultural productivity, especially in regions with high soil salinity. With the increasing salinization of soils due to climate change, developing salt-tolerant crops has become essential for ensuring food security. This review consolidates recent advances in plant genetics, transcription factors (TFs), and next-generation sequencing (NGS) technologies that are pivotal for enhancing salt stress tolerance in crops.

Securing healthcare medical image information using advance morphological component analysis, information hiding systems, and hybrid convolutional neural networks on IoMT.

Health care images contain a variety of imaging information that has specific features, which can make it challenging to assess and decide on the methods necessitated to safeguard the highly classified visuals from unauthorized exposure during transmission in a communication channel. As a result, this proposed approach utilizes a variety of techniques that will enhance the quality of textual healthcare images, communicate information securely, and interpret textual data from healthcare visuals without difficulty. Natural interference, primarily on the receiver side, reduces text-based healthcare image contrast, and numerous artifacts and adjacent picture element values impede diagnosis.

Face mask identification with enhanced cuckoo optimization and deep learning-based faster regional neural network.

A mask identification and social distance monitoring system using Unmanned Aerial Vehicles (UAV) in the outdoors has been proposed for a health establishment. The above approach performed surveillance of the surrounding area using cameras installed in UAVs and internet of things technologies, and the captured images seem useful for tracking the entire environment. However, innate images from unmanned aerial vehicles show an adaptable visual effect in an uncontrolled environment, making face-mask detection and recognition harder.

Case Report: Intrahepatic cholestasis: a diagnostic dilemma.

Cholestasis is an impairment of bile formation or bile flow. The mechanisms of cholestasis can be broadly classified into intrahepatic and extrahepatic. Most of the time, etiology can be determined with proper history, physical examination, and diagnostic testing including laboratory and imaging tests.

Soil compaction sensing mechanisms and root responses.

Soil compaction is an agricultural challenge with profound influence on the physical, chemical, and biological properties of the soil. It causes drastic changes by increasing mechanical impedance, reducing water infiltration, gaseous exchange, and biological activities. Soil compaction hinders root growth, limiting nutrient and water foraging abilities of plants.

Investigation of structural and electrical properties of electrolyte LaGaO for solid oxide fuel cell.

Context: Electrochemical devices such as solid oxide fuel cells (SOFCs) allow the direct transformation of fuel's chemical energy into electrical power. Even though YSZ electrolyte-based conventional SOFCs are widely used in both laboratories and on a commercial scale, developing alternative ion-conducting electrolytes is crucial for enhancing SOFC performance at lower operating temperatures. In this work, we conducted a thorough computational analysis on the characteristics of Sr- and Mg-doped superior oxide ion conductors.

Root Circumnutation Reduces Mechanical Resistance to Soil Penetration.

Root circumnutation, the helical movement of growing root tips, is a widely observed behaviour of plants. However, our mechanistic understanding of the impacts of root circumnutation on root growth and soil exploration is limited. Here, we deployed a unique combination of penetrometer measurements, X-ray computed tomography and time-lapse imaging, and cavity expansion modelling to unveil the effects of root circumnutation on the mechanical resistance to soil penetration.

Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and and investigations.

A total of 18 heterocyclic derived conjugated dienones (CD1-CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity. Among the analyzed molecules, CD11 and CD14 showed notable inhibitory potentials against MAO-B, with half-maximal inhibitory concentration (IC) values of 0.063 ± 0.

Modified Tal Score as a Predictor of Outcome in Bronchiolitis: A Cross-Sectional Study in Nepal.

Introduction Bronchiolitis is a leading cause of respiratory distress and hospitalizations among infants and young children worldwide. Despite its prevalence, predicting the severity and outcomes of bronchiolitis remains challenging. Standardized criteria for severity assessment are essential for improving patient care and resource allocation.

pH-Responsive magnetic nanocarriers for chelator-free bimodal (MRI/SPECT-CT) image-guided chemo-hyperthermia therapy in human breast carcinoma.

Although chemotherapy with magnetic nanocarriers has witnessed significant advancement in the field of cancer treatment, multimodal diagnosis and combinatorial therapy using a single nanoplatform will have much better efficacy in achieving superior results. Herein, we constructed a smart theranostic system by combining pH-sensitive tartaric acid-stabilized FeO magnetic nanocarriers (TMNCs) with SPECT imaging and a chemotherapeutic agent for image-guided chemo-hyperthermia therapy. The carboxyl-enriched exteriors of TMNCs provided sites for the conjugation of a chemotherapeutic drug (doxorubicin hydrochloride, DOX) and radiolabeling (Ce).

Sex differences in genotype frequency and the risk of polycythemia associated with rs13419896 and rs2790859 among Tibetan highlanders living in Tsarang, Mustang, Nepal.

Background: Tibetan highlanders have adapted to hypoxic environments through genetic mechanisms that avoid hemoglobin concentration increases and prevent polycythemia. Recently, sex differences in hemoglobin dynamics with age have been reported among Tibetan highlanders living in Tsarang. Additionally, concerns have been raised that dietary changes associated with modernization may increase the risk of polycythemia and lifestyle-related diseases among Tibetan highlanders.

Crosstalk Between Macrophages and Breast Cancer Cells: Networking Within Tumors.

Tumor associated macrophages (TAMs) are one of the most prominent immune cells in the breast tumor microenvironment (TME). TAMs are categorised into classically activated anti-tumorigenic M1 and alternatively activated pro-tumorigenic M2 macrophages. TAMs are known to promote cancer pathogenesis by facilitating cancer cell and cancer stem cell growth, angiogenesis, immune evasion, invasion, and migration.

A Dual-Adjuvanted Parenteral-Intranasal Subunit Nanovaccine generates Robust Systemic and Mucosal Immunity Against SARS-CoV-2 in Mice.

Existing parenteral SARS-CoV-2 vaccines produce only limited mucosal responses, essential for reducing transmission and achieving sterilizing immunity. Appropriately designed mucosal boosters can overcome the shortcomings of parenteral vaccines and enhance pre-existing systemic immunity. Here, a new protein subunit nanovaccine is developed by utilizing dual-adjuvanted (RIG-I: PUUC RNA and TLR-9: CpG DNA) polysaccharide-amino acid-lipid nanoparticles (PAL-NPs) along with SARS-CoV-2 S1 trimer protein, that can be delivered both intramuscularly (IM) and intranasally (IN) to generate balanced mucosal-systemic SARS-CoV-2 immunity.

Performance of Fujifilm Dengue NS1 Antigen Rapid Diagnosis Kit Compared to Quantitative Real-Time Polymerase Chain Reaction.

Dengue is a viral infection caused by the dengue virus (DENV), transmitted to humans through the bite of infected mosquitoes. About half of the world's population is now at risk of dengue, which represents a global public health concern, especially in tropical and subtropical countries. Early detection of the viral infection is crucial to manage the disease; hence, effective rapid diagnostic tests are essential.