Management of Proximal Femur Aneurysmal Bone Cyst with 10-year Follow-up - A Case Report.

Introduction: Aneurysmal bone cyst is a benign, most often non-neoplastic lesion affecting the bone. Malignant transformation is reported in certain cases, although rare. It commonly occurs in young adults with around 75% of the cases occurring in the first two decades and 95% occurring in the first 3 decades.

Survey of awareness and attitudes to the management of fragility fractures among the membership of the Asia Pacific Orthopaedic Association.

Unlabelled: A survey of awareness and attitudes to the management of fragility fractures among the membership of the Asia Pacific Orthopaedic Association conducted in 2022 found considerable variation in care across the region. A Call to Action is proposed to improve acute care, rehabilitation and secondary fracture prevention across Asia Pacific.

Purpose: Fragility fractures impose a substantial burden on older people and their families, healthcare systems and national economies.

Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants.

Coronaviruses have been the causative agent of three epidemics and pandemics in the past two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing coronavirus therapeutic is desirable not only to prevent and treat COVID-19, but also to provide protection for high-risk populations against future emergent coronaviruses. As all coronaviruses use spike proteins on the viral surface to enter the host cells, and these spike proteins share sequence and structural homology, we set out to discover cross-reactive biologic agents targeting the spike protein to block viral entry.

A Case Report on Surgical Excision of Intracapsular Osteochondroma of Femur Neck using Mini-Arthrotomy without Hip Dislocation in a Young Female with Hereditary Multiple Exostoses.

Introduction: Osteochondromas are the most common benign bone tumors. They probably are developmental malformations rather than true neoplasms and are thought to originate within the periosteum as small cartilaginous nodules. The lesions consist of a bony mass produced by progressive endochondral ossification of a growing cartilaginous cap.

Inter-Bragg crystallographic phase retrieval from shape transforms, stacking faults and substitutional disorder.

One of the brilliant ideas of John Spence when he saw the first diffraction patterns from the Linac Coherent Light Source was that one could solve the crystallographic phase problem by utilising the intensities between Bragg peaks. Because these intensities are due to the Fourier transform of the shape of the crystal, the approach came to be known as "shape-transform phasing." Shape-transform phasing was developed over the next ten years and formed the basis for many other interesting ideas and pursuits.

Enhanced antimicrobial and antioxidant properties of Nano chitosan and pectin based biodegradable active packaging films incorporated with fennel ( essential oil and potato ( peel extracts.

Unlabelled: Active packaging materials are generally prepared by incorporating antimicrobial agents. The main objective of the present research is the development and characterization of active packaging with Nano chitosan and pectin. Active packaging film was prepared by incorporating essential oil of Fennel (EOF) along with potato peel extract (PPE) to improve the antioxidant and antimicrobial property of the film.

Explication of mechanism governing atmospheric degradation of 3D-printed poly(lactic acid) (PLA) with different in-fill pattern and varying in-fill density.

With the popularity of 3D-printing technology, poly(lactic acid) (PLA) has become a very good option for layer by layer printing as it is easy to handle, environment friendly, has low costs and most importantly, it is highly adaptable to different materials including carbon, nylon and some other fibres. PLA is an aliphatic poly-ester that is 100% bio-based and is bio-degradable as well. It is one of the rare bio-polymers to compete with traditional polymers in terms of performance and environmental impact.

Surgical Management of Aggressive Knee Tuberculosis with Open Subtotal Synovectomy - A Case Report and Review of Literature.

Introduction: Skeletal tuberculosis (TB) accounts for approximately 10-35% of the extra-pulmonary cases, where knee TB accounts for around 8% of extra-pulmonary TB cases after hip and spine. In about one-third of patients with extra-pulmonary TB, pulmonary TB is concomitantly found. The management of knee TB poses an initial diagnostic challenge due to its non-specific symptoms and absence of constitutional symptoms after which depending on the response to AKT - surgical intervention open or arthroscopic could be contemplated.

Management of Short Proximal Femur Nail Peri-Implant Fracture of Femur Shaft with Implant Removal and Long Distal Femur Locking Plate and Bone Grafting - A Case Report.

Introduction: The rising demographic trend towards elderly population and increased incidence of osteosynthesis of proximal femur fractures are associated with increased recurrent falls and rise in incidence of peri- implant fractures.

Case Report: Here, we present a difficult case of a peri-implant femur shaft fracture in a 55-year-old male, with stuck short proximal femur nail (PFN) removal followed by long distal femur plating with bone grafting showing good fracture union at 1 year with satisfactory functional outcome.

Conclusion: Peri- implant femur fractures are quite rare and more commonly occur in elderly.

studies disclose the underlying link between binding affinity and redox potential in laccase isoforms.

Laccases are copper-containing enzymes belonging to the family of multicopper oxidases (MCOs). All MCOs use molecular oxygen to oxidize a wide range of organic compounds by radical catalysis. One of the key fundamental properties of laccases is having high or low redox potentials depending on the active site organization.

Hexamerization of Anti-SARS CoV IgG1 Antibodies Improves Neutralization Capacity.

The SARS-CoV-2 pandemic and particularly the emerging variants have deepened the need for widely available therapeutic options. We have demonstrated that hexamer-enhancing mutations in the Fc region of anti-SARS-CoV IgG antibodies lead to a noticeable improvement in IC in both pseudo and live virus neutralization assay compared to parental molecules. We also show that hexamer-enhancing mutants improve C1q binding to target surface.

A Case Report of Humerus Shaft Osteomyelitis Secondary to Local Skin Infection Treated with Saucerization.

Introduction: Osteomyelitis of the humerus shaft after local skin infection is rare clinical entity, all the principles of tibia and femur osteomyelitis are used in the humerus osteomyelitis. Early detection is best done by the magnetic resonance imaging. Surgical debridement and curettage with IV antibiotics gives good clinical outcome in the patient.

Joint iterative reconstruction and 3D rigid alignment for X-ray tomography.

X-ray tomography is widely used for three-dimensional structure determination in many areas of science, from the millimeter to the nanometer scale. The resolution and quality of the 3D reconstruction is limited by the availability of alignment parameters that correct for the mechanical shifts of the sample or sample stage for the images that constitute a scan. In this paper we describe an algorithm for marker-free, fully automated and accurately aligned and reconstructed X-ray tomography data.

Nutrient use efficiency (NUE) of wheat (Triticum aestivum L.) as affected by NPK fertilization.

Nutrient use efficiency is crucial for increasing crop yield and quality while reducing fertilizer inputs and minimizing environmental damage. The experiments were carried out in silty clay loam soil of Lalitpur, Nepal, to examine how different amounts of nitrogen (N), phosphorus (P), and potassium (K) influenced crop performance and nutrient efficiency indices in wheat during 2019/20 and 2020/21. The field experiment comprised three factorial randomized complete block designs that were replicated three times.

Management of Distal Femur Periprosthetic Fracture in an Elderly Patient by Open Reduction and Internal Fixation With Locking Plate Osteosynthesis -: A Case Report.

Introduction: Distal femur periprosthetic fractures are rare entityies and difficult to manage. Supracondylar femur fractures are most common amongst periprosthetic fractures. They can be managed by various modalities.

Humeral Shaft Fracture Sustained During Arm Wrestling with Review of Factors Contributing to its Causation.

Introduction: Humeral shaft fractures are the most common injury sustained in arm wrestling, and its various biomechanical, anatomical, kinematic and electromyographic aspects have been studied and reported. We present a series of six cases of humeral shaft fractures in the arm wrestlers and a review of basic science studies to determine the factors contributing to their causation.

Materials And Methods: Six humeral shaft fractures associated with arm wrestling were treated between December 2018 and January 2020.

What is the Quality of Life of Transtibial Amputees in Brunei Darussalam?

Introduction: Lower limb amputations have a profound impact on the quality of life (QoL) of the patients. This study was done to assess the QoL of patients with transtibial (below-the-knee) amputations (TTA) and transtibial amputees fitted with prosthesis.

Material And Methods: A case-control study of patients who had undergone TTA from 2015 to 2018 was conducted in Raja Isteri Pengiran Anak Saleha Hospital (RIPAS).

Intertrochanteric Fracture of the Femur in an Ankylosed Hip: A Case Report.

Intertrochanteric fractures of the femur in ankylosed hips are extremely rare. The aims of the operative management for elderly patients with intertrochanteric fractures are to prevent general complications, to maintain mobility, and to relieve pain. The optimal management to achieve these goals is not clear.

On the existence of a perennial river in the Harappan heartland.

The legendary river Saraswati of Indian mythology has often been hypothesized to be an ancient perennial channel of the seasonal river Ghaggar that flowed through the heartland of the Bronze Age Harappan civilization in north-western India. Despite the discovery of abundant settlements along a major paleo-channel of the Ghaggar, many believed that the Harappans depended solely on monsoonal rains, because no proof existed for the river's uninterrupted flow during the zenith of the civilization. Here, we present unequivocal evidence for the Ghaggar's perennial past by studying temporal changes of sediment provenance along a 300 km stretch of the river basin.

X-ray focusing with efficient high-NA multilayer Laue lenses.

Multilayer Laue lenses are volume diffraction elements for the efficient focusing of X-rays. With a new manufacturing technique that we introduced, it is possible to fabricate lenses of sufficiently high numerical aperture (NA) to achieve focal spot sizes below 10 nm. The alternating layers of the materials that form the lens must span a broad range of thicknesses on the nanometer scale to achieve the necessary range of X-ray deflection angles required to achieve a high NA.

The eruptive tempo of Deccan volcanism in relation to the Cretaceous-Paleogene boundary.

Late Cretaceous records of environmental change suggest that Deccan Traps (DT) volcanism contributed to the Cretaceous-Paleogene boundary (KPB) ecosystem crisis. However, testing this hypothesis requires identification of the KPB in the DT. We constrain the location of the KPB with high-precision argon-40/argon-39 data to be coincident with changes in the magmatic plumbing system.

Ab initio structure determination from experimental fluctuation X-ray scattering data.

Fluctuation X-ray scattering (FXS) is an emerging experimental technique in which X-ray solution scattering data are collected from particles in solution using ultrashort X-ray exposures generated by a free-electron laser (FEL). FXS experiments overcome the low data-to-parameter ratios associated with traditional solution scattering measurements by providing several orders of magnitude more information in the final processed data. Here we demonstrate the practical feasibility of FEL-based FXS on a biological multiple-particle system and describe data-processing techniques required to extract robust FXS data and significantly reduce the required number of snapshots needed by introducing an iterative noise-filtering technique.

Free-electron laser data for multiple-particle fluctuation scattering analysis.

Fluctuation X-ray scattering (FXS) is an emerging experimental technique in which solution scattering data are collected using X-ray exposures below rotational diffusion times, resulting in angularly anisotropic X-ray snapshots that provide several orders of magnitude more information than traditional solution scattering data. Such experiments can be performed using the ultrashort X-ray pulses provided by a free-electron laser source, allowing one to collect a large number of diffraction patterns in a relatively short time. Here, we describe a test data set for FXS, obtained at the Linac Coherent Light Source, consisting of close to 100 000 multi-particle diffraction patterns originating from approximately 50 to 200 Paramecium Bursaria Chlorella virus particles per snapshot.