Exploring the physiological, biochemical, and enzymatic responses of Vigna mungo varieties to Mungbean Yellow Mosaic India Virus (MYMIV) infection.

This study aims to enhance sustainable disease management in black gram by identifying varieties resistant to Mungbean Yellow Mosaic India Virus (MYMIV). We screened sixteen black gram genotypes, assessing physiological, biochemical and enzymatic basis. Results revealed a range of resistance levels, with PANT URD-19 showing the highest resistance (PDI 0.

Recent advances in phytocompounds as potential Chikungunya virus non-structural protein 2 protease antagonists: A systematic review.

Background: The mosquito-borne pathogenic alphavirus known as Chikungunya virus (CHIKV) is becoming a greater hazard to public health, which causes thousands of cases annually in both rural and urban areas of many different nations throughout the world. Finding and creating new leads for the CHIKV virus is crucial because there are currently no effective medications or vaccinations against it. The non-structural protein 2 (nsP2) protease has emerged as a promising target for therapeutic intervention due to its crucial role in viral replication.

Modified intralesional acyclovir therapy in the management of recalcitrant palmoplantar and ungual warts: a case series of 14 patients.

This study evaluated the efficacy and safety of Intralesional Acyclovir in the treatment of recalcitrant palmoplantar and ungual warts in 14 patients(7 male and 7 female) of mean age 24.5 +- 8.19 years.

The challenges of frontline health managers during the COVID-19 pandemic in India: A framework analysis study.

Background: Coronavirus was first officially reported in Wuhan city of China in December 2019. As this novel coronavirus spread rapidly throughout the world, health care workers faced many difficulties addressing the pandemic. In the present study, we explored the challenges faced by front-line health managers on human resource management, execution of the central policies, and training and in formulating innovative approaches during the coronavirus disease 2019 (COVID-19) pandemic in India.

Program and Institutional Coordinator Well-Being: Results From a National Survey.

Purpose: This study explores the mental health and well-being, overall job satisfaction, likelihood to leave position, and perceptions of job satisfiers and stressors and dissatisfiers in a national sample of program and institutional coordinators in graduate medical education (GME).

Method: Between August and September 2022, 11,887 program and institutional coordinators and managers with email addresses listed in the Accreditation Council for Graduate Medical Education database were emailed a survey link. The survey queried mental health using the Patient Health Questionnaire 8 depression scale, Generalized Anxiety Disorder 7, and a 2-item burnout scale derived from the Maslach Burnout Inventory; overall satisfaction with work; likelihood to leave work; and drivers of satisfaction and dissatisfaction.

Harnessing mixed-phase MoS for efficient room-temperature ammonia sensing.

Molybdenum disulfide (MoS), a notable two-dimensional (2D) material, has attracted considerable interest for its potential applications in gas sensing, despite its typically insulating characteristics, which have limited its practical use. In this study, we present the use of mixed phase MoS (1T@2H-MoS) to overcome sensing limitations of MoS material by enhancing its conductivity and demonstrating its high-performance characteristics for sensing ammonia (NH) at room temperature (20 °C). The 1T@2H-MoS was synthesized a hydrothermal process, and the coexistence of two different phases (the 1T and 2H phases) was confirmed by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and Raman spectroscopy.

To Evaluate Structured Competency-Based Curriculum for Health Programs among Community Medicine Postgraduates: Mixed Method Approach.

Background: The postgraduate curriculum needs to be given a definite shape so as to make health programs more intensive and integrative. In the present scenario, most of the information is unclear and infrequent. A structured public health competency-based education is an important aspect to consider for integrative health care.

Smooth Muscle and Adenoma-Like Renal Tumor (SMART)- A Rare Biphasic Renal Tumor with a Review.

Smooth muscle and adenoma-like renal tumor (SMART) is a biphasic tumor composed of cytologically bland stromal and epithelial components. It has many histopathological mimickers. A 57-year-old man presented with a left renal mass.

Non-convergence of the blinking timescale of twelve-faceted perovskite nanocrystals observed through an advanced fluorescence correlation spectroscopy study.

Single-particle photoluminescence measurements have been extensively utilized to investigate the charge carrier dynamics in quantum dots (QDs). Among these techniques, single dot blinking studies are effective for probing relatively slower processes with timescales >10 ms, whereas fluorescence correlation spectroscopy (FCS) studies are suited for recording faster processes with timescales typically <1 ms. In this study, we utilized scanning FCS (sFCS) to bridge the ms gap, thereby enabling the tracking of carrier dynamics across an extended temporal window ranging from μs to subsecond.

Gridded global dataset of industrial water use predicted using the Random Forest.

Spatially distributed industrial water use (IWU) data are essential for effective region-specific water resource management. Such data are often scarce in underdeveloped and developing countries. We propose a random forest regression model to predict IWU at a spatial resolution of 0.

Effects of Lactobacillus spp. on Helicobacter pylori: A Promising Frontier in the Era of Antibiotic Resistance.

Helicobacter pylori, a pathogenic bacterium responsible for multiple gastrointestinal disorders, has emerged as a major global concern due to rise in antibiotic resistance. Unwanted side effects of antibiotics therapy are further complicating the treatment strategies. Consequently, an alternative approach, using probiotics has emerged as a promising solution for treating H.

Shikonin Stimulates Mitochondria-Mediated Apoptosis by Enhancing Intracellular Reactive Oxygen Species Production and DNA Damage in Oral Cancer Cells.

Phytotherapy has rendered a new insight towards the treatment of various cancers, including oral cancer with fewer side effects, over the traditional chemotherapeutic drugs to overcome chemoresistance. Shikonin (Shk) is a natural biologically active alkaloid found in the Lithospermum erythrorhizon plant's root. It has potent cytotoxic activities against various cancers.

Seeing nanoscale electrocatalytic reactions at individual MoS particles under an optical microscope: probing sub-mM oxygen reduction reaction.

MoS is a promising electrocatalytic material for replacing noble metals. Nanoelectrochemistry studies, such as using nanoelectrochemical cell confinement, have particularly helped in demonstrating the preferential electrocatalytic activity of MoS edges. These findings have been accompanied by considerable research efforts to synthesize edge-abundant nanomaterials.

A Schiff-Base Molecular Probe for Selective Fluorescence Sensing of Maleic Acid with Recognition of Maleic Acid in Food Additives and Cell Imaging.

The 2,4-dinitrophenylhydrazine based Schiff base (L) acts as an effective fluorescence sensor for the selective detection of maleic acid. The detection limit of L towards maleic acid is observed to be 1.29 × 10 M.

Developing peptide-based fusion inhibitors as an antiviral strategy utilizing coronin 1 as a template.

Enveloped viruses enter the host cells by endocytosis and subsequently fuse with the endosomal membranes, or fuse with the plasma membrane at the cell surface. The crucial stage of viral infection, regardless of the route taken to enter the host cell, is membrane fusion. The present work aims to develop a peptide-based fusion inhibitor that prevents membrane fusion by modifying the properties of the participating membranes, without targeting a protein.

An interventional study to assess the impact of behavior modification therapy on motivation level for tobacco cessation among adult tobacco users in a resettlement colony of South Delhi.

Background: Tobacco use remains a significant global health challenge, contributing to 8 million annual deaths and potentially reaching 1 billion deaths in the 21 century. Despite taking efforts like India's National Tobacco Control Program, the country faces a persistent 39% tobacco use prevalence, particularly in low-income communities like those from Madanpur Khadar, Delhi. This study explores the effectiveness of behavior modification therapy in addressing this challenge.

COVID-19 Vaccination Hesitancy among the General Population: A Gender-Based Review and Bibliometric Analysis.

December 2019 was momentous since it experienced the trajectory of another novel pathogenic HCoV recognized as 2019-nCoV in Wuhan, China, which further unfurled to all countries on the entire globe at lightning speed. The Majority of COVID-19 vaccines are being manufactured using protein subunits, viral vectors, inactivated viruses, as well as DNA and mRNA vaccine platforms. This study aimed to conduct a gender-based review of COVID-19 vaccine hesitancy among the general population and bibliometric analysis.

Catalytic stereoselective synthesis of cyclopentanones from donor-acceptor cyclopropanes and -generated ketenes.

A dual InBr-EtAlCl Lewis acidic system was found to be optimal for promoting the diastereoselective (3 + 2)-cycloaddition of donor-acceptor cyclopropanes with -generated ketenes to form cyclopentanones. The desired products were formed in good to excellent yields (70-93% for 16 examples) and with good to excellent diastereoselectivity and enantiospecificity.

Atropisomerism Observed in Galactose-Based Monosaccharide Inhibitors of Galectin-3 Comprising 2-Methyl-4-phenyl-2,4-dihydro-3-1,2,4-triazole-3-thione.

Galectin-3 (Gal-3) is a carbohydrate binding protein that has been implicated in the development and progression of fibrotic diseases. Proof-of-principal animal models have demonstrated that inhibition of Gal-3 is a potentially viable pathway for the treatment of fibrosis─with small molecule Gal-3 inhibitors advanced into clinical trials. We hereby report the discovery of novel galactose-based monosaccharide Gal-3 inhibitors comprising 2-methyl-4-phenyl-2,4-dihydro-3-1,2,4-triazole-3-thione (compound ) and 4-phenyl-4-1,2,4-triazole (compound ).