Calorimetry-based profiling of blood plasma from colorectal cancer patients.

Background: Differential scanning calorimetry (DSC), a highly sensitive technique for resolving thermally-induced protein folding/unfolding transitions, recently was recognized as a novel tool for disease diagnosis and monitoring. To further elaborate this approach we have applied DSC in a study of blood plasma from patients with colorectal cancer (CRC) at different stages of tumor development and localization.

Methods: Blood plasma from patients diagnosed with CRC was analyzed by DSC.