Publications by authors named "Panaiotti L"
Unlabelled: The individual approach to determining colon resection extension, known as tailored surgery, has been actively discussed for several years. However, despite the consistency and validity of the idea, it still has few followers, primarily due to the lack of high-level evidence confirming the validity of this approach.
Objective: To determine whether the boundaries of the lymphatic outflow area, mapped with indocyanine green, match the lymphogenic metastasis area according to the surgical specimens' pathological study.
Article Synopsis
- The incidence of early-onset colorectal cancer (diagnosed in individuals under 50) is on the rise globally, with distinct clinical and molecular characteristics compared to late-onset cases.
- Factors contributing to this increase may include diet, obesity, antibiotic use, and changes in gut microbiome, with most cases occurring sporadically rather than being genetically inherited.
- There is a need for tailored preventive and therapeutic approaches for early-onset colorectal cancer, as younger patients often present with more severe disease stages but similar outcomes to older patients after treatment.
Background: It remains unclear whether extended lymphadenectomy provides oncological advantages in colorectal cancer. This multicentre RCT aimed to address this issue.
Methods: Patients with resectable primary colonic cancer were enrolled in four hospitals registered in the COLD trial, and randomized to D2 or D3 dissection in a 1 : 1 ratio.
Background: The extent of lymph node dissection in colonic cancer surgery remains arguable, and evidence from RCTs regarding extended lymph node dissection outcomes is lacking. This study aimed to compare the long-term results of D3 lymph node dissection with those of D2 dissection.
Methods: This is a multicentre RCT.