Publications by Panagiou Mavroeidi

Publications by authors named "Panagiou Mavroeidi"

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Are Terminal Alkynes Necessary for MAO-A/MAO-B Inhibition? A New Scaffold Is Revealed.

Panagiou Mavroeidi Leandros P Zorba Nikolaos V Tzouras Stavros P Neofotistos Nikitas Georgiou

Molecules

May 2024

A versatile family of quaternary propargylamines was synthesized employing the KA multicomponent reaction, through the single-step coupling of a number of amines, ketones, and terminal alkynes. Sustainable synthetic procedures using transition metal catalysts were employed in all cases. The inhibitory activity of these molecules was evaluated against human monoaminoxidase (hMAO)-A and hMAO-B enzymes and was found to be significant.

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- Panagiou Mavroeidi's recent research emphasizes the synthesis of a family of quaternary propargylamines through sustainable methods, specifically utilizing the KA multicomponent reaction to couple amines, ketones, and terminal alkynes.
- The study investigates the potential necessity of terminal alkynes in the inhibition of human monoaminoxidase (hMAO)-A and hMAO-B, contributing valuable insights to enzyme inhibition dynamics.
- Findings indicate that the synthesized molecules exhibit significant inhibitory activity against the hMAO enzymes, which could have implications for the development of new therapeutic agents in treating related disorders.

Publications by authors named "Panagiou Mavroeidi"

Are Terminal Alkynes Necessary for MAO-A/MAO-B Inhibition? A New Scaffold Is Revealed.

Synopsis of recent research by authors named "Panagiou Mavroeidi"