Primary aldosteronism in hypertensive patients: clinical implications and target therapy.

Background: The prevalence of primary aldosteronism (PA) in hypertensive patients varies according to diagnostic testing and ascertained normal cut-offs. The aim of this case-control study was to confirm the high prevalence of PA in a large hypertensive population and evaluate the antihypertensive effect of mineralocorticoid receptor antagonists (MRA) treatment.

Material And Methods: We investigated 327 hypertensive and 90 matched normotensive subjects with normal adrenal imaging.