Publications by authors named "Panagiotis Smyrnis"
Article Synopsis
- Immune checkpoint inhibitor (ICI) therapies used in cancer treatment may elevate the risk of heart-related issues in cancer survivors by worsening atherosclerosis, a condition affecting artery health.
- Researchers have identified a network of immune cell interactions within atherosclerotic plaques that can be targeted by ICIs, where a specific group of dendritic cells plays a significant role in immune signaling.
- The study also indicates that factors like type 2 diabetes and lipid-lowering medications can alter how immune cells interact, potentially affecting plaque inflammation and highlighting the need for strategies to reduce heart disease risk in patients undergoing ICI treatments.
Atherosclerosis is fueled by a failure to resolve lipid-driven inflammation within the vasculature that drives plaque formation. Therapeutic approaches to reverse atherosclerotic inflammation are needed to address the rising global burden of cardiovascular disease (CVD). Recently, metabolites have gained attention for their immunomodulatory properties, including itaconate, which is generated from the tricarboxylic acid-intermediate cis-aconitate by the enzyme Immune Responsive Gene 1 (IRG1/ACOD1).
View Article and Find Full Text PDFEndometriosis constitutes a benign condition, occurring in 10%-12% of menstruating women. Bowel involvement is estimated to occur in 5%-12% with the rectosigmoid region involved in up to 90% of these cases. We present the case of a 45-year-old Caucasian female patient with rectosigmoid endometriosis.
View Article and Find Full Text PDFPurpose: The Emergency Surgery Score (ESS) is a reliable point-based score that predicts mortality and morbidity in emergency surgery patients. However, it has been validated only in the U.S.
View Article and Find Full Text PDFStudy Design: Serial screening of Roma children for idiopathic scoliosis.
Objective: To confirm or reject the observation that the prevalence of scoliosis is reduced in the Roma population and possibly to explain it.
Materials And Methods: The authors conducted serial screening for idiopathic scoliosis of 1,034 indigenous Roma children (542 boys and 492 girls), aged 4-18 years (857 children were aged 8-18 years) from 1997 to 2011.