Publications by authors named "Panagiotis Liakopoulos"
Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine.
Cancer Res Commun
December 2024
Article Synopsis
- CD8+ T cells play a vital role in fighting cancer, but their functionality is compromised in higher-risk myelodysplastic neoplasms (HR-MDS) and acute myeloid leukemia (AML).
- An analysis of 104 pre-treatment bone marrow samples revealed that patients who did not respond to azacitidine therapy had higher levels of a specific CD8+ T cell subset (CD57+CXCR3+), which was linked to worse survival outcomes.
- The study also highlighted that successful treatment responses were associated with stronger IFN signaling, while non-responders showed increased TGF-β signaling, suggesting that combining TGF-β inhibitors with azacitidine could improve treatment in these cancer types.
Transcription Factors (TFs) are the main regulators of gene expression, controlling among others cell homeostasis, identity, and fate. TFs may either act synergistically or antagonistically on nearby regulatory elements and their interplay may activate or repress gene expression. The family of NF-κB TFs is among the most important TFs in the regulation of inflammation, immunity, and stress-like responses, while they also control cell growth and survival, and are involved in inflammatory diseases and cancer.
View Article and Find Full Text PDFCongenital diaphragmatic hernia is a structural birth defect of the diaphragm, with lung hypoplasia and persistent pulmonary hypertension. Aside from vascular defects, the lungs show a disturbed balance of differentiated airway epithelial cells. The Sry related HMG box protein SOX2 is an important transcription factor for proper differentiation of the lung epithelium.
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