Topical Treatment of Skin Injury Inflicted in Mice by X-Ray Irradiation.

Background/aims: There is no treatment, without side effects, efficiently preventing or curing skin burns, caused by radiotherapy. A new experimental topical treatment protocol was assessed in mice receiving orthovoltage X-rays at an equivalent dose to that applied to human breast cancer patients in conventional radiotherapy.

Methods: SKH-HR2 female hairless mice were irradiated on their dorsum with a total dose of 4,300 cGy during a 1-month period (20 fractions).

Mechanical and dose delivery accuracy evaluation in radiosurgery using polymer gels.

The polymer gel-Magnetic Resonance Imaging (MRI) dosimetry technique was employed to evaluate the mechanical and dose delivery accuracy in Leksell gamma knife stereotactic radiosurgery for the treatment of multiple targets. Two different polymer gel dosimeter formulations that have been reported in the literature were prepared in-house. A plan for the treatment of four brain metastases (targets) was generated.

Dose verification in clinical IMRT prostate incidents.

Purpose: In view of the need for dose-validation procedures on each individual intensity-modulated radiation therapy (IMRT) plan, dose-verification measurements by film, by ionization chamber, and by polymer gel-MRI dosimetry were performed for a prostate-treatment plan configuration. Treatment planning system (TPS) calculations were evaluated against dose measurements.

Methods And Materials: Intensity-modulated radiation therapy (IMRT) treatments were planned on a commercial TPS.

Dosimetric calculations and VIPAR polymer gel dosimetry close to the microSelectron HDR.

In the present study, different dosimetric methods were investigated for their ability to predict the energy dose in the vicinity of the microSelectron HDR 192Ir brachytherapy source. The results of a time-efficient Sievert integral model of proven accuracy in the cm distance range from all 192Ir sources were benchmarked against accurate Monte Carlo derived dosimetric data in the close vicinity of the source. This comparison revealed that the Sievert model is capable of accurate dosimetry even in the mm distance range from the source.