3D Molecular-Reconstructed Disordered Precursor Toward Highly Stable Porous Ramie Carbon.

Biomass porous carbon possesses broad application prospects in the field of energy storage. However, soft biomass materials with high cellulose content and orders structure usually represent low mechanical strength, which leads to unstable pore structure of prepared porous carbon and even prone to collapse, thus reducing the quality and stability of carbon. Herein, a simple molecular reconstruction method is proposed to effectively re-construct 3D disordered ramie precursors (DRPs) by regulating the chemical interaction of hydrogen bonds.

Stress Release of Zincophilic N-Doped Carbon@Sn Composite on High-Curvature Surface of Zinc Foam for Dendrite-Free 3D Zinc Anode.

Commercial 3D zinc foam anodes with high deposition space and ion permeation have shown great potential in aqueous ion batteries. However, the local accumulated stress from its high-curvature surface exacerbates the Zn dendrite issue, leading to poor reversibility. Herein, we have employed zincophilic N-doped carbon@Sn composites (N-C@Sn) as nano-fillings to effectively release the local stress of high curvature surface of 3D Zn foams toward dendrite-free anode in aqueous zinc ion battery (AZIB).

Single-Cell Analysis Reveals the Cellular and Molecular Changes of Liver Injury and Fibrosis in Mice During the Progression of Infection.

Schistosomiasis is a parasitic disease that poses a serious threat to human health. However, the pathogenic mechanism during the progression of infection remains unclear. In order to elucidate this mechanism, we used single-cell RNA sequencing (scRNA-seq) to investigate the transcriptome characteristics of the cellular (single-cell) landscape in the livers of mice infected with , which were divided into three groups: uninfected mice (0 week (w)), infected mice at 6 w post-infection (the acute phase), and infected mice at 10 w post-infection (the chronic phase).

Meta-analysis of gut microbiota biodiversity in patients with polycystic ovary syndrome based on medical images.

PCOS is thought to be associated with metabolic disorders, endocrine disorders, and reproductive system problems. By collecting relevant literature and conducting meta-analyses, we integrated data from multiple studies to enhance the reliability of the analysis results. Studies with medical image data were selected to ensure the accuracy and credibility of the studies.

Poly(ethylene) Oxide Electrolytes for All-Solid-State Lithium Batteries Using Microsized Silicon/Carbon Anodes with Enhanced Rate Capability and Cyclability.

Silicon (Si) has been widely studied as one of the promising anodes for lithium-ion batteries (LIBs) because of its ultrahigh theoretical specific capacity and low working voltage. However, the poor interfacial stability of silicon against conventional liquid electrolytes has largely impeded its practical use. Therefore, the combination of silicon-based anodes and solid electrolytes has attracted a great deal of attention in recent years.

The egg ribonuclease SjCP1412 accelerates liver fibrosis caused by infection involving damage-associated molecular patterns (DAMPs).

Schistosomiasis, a parasite infectious disease caused by , often leads to egg granuloma and fibrosis due to the inflammatory reaction triggered by egg antigens released in the host liver. This study focuses on the role of the egg antigens CP1412 protein of (SjCP1412) with RNase activity in promoting liver fibrosis. In this study, the recombinant egg ribonuclease SjCP1412, which had RNase activity, was successfully prepared.

Few Layer TiC MXene-Based Label-Free Aptasensor for Ultrasensitive Determination of Chloramphenicol in Milk.

Quantitative detection of veterinary drug residues in animal-derived food is of great significance. In this work, a simple and label-free electrochemical aptasensor for the highly sensitive detection of chloramphenicol (CAP) in milk was successfully developed based on a new biosensing method, where the single- or few-layer TiC MXene nanosheets functionalized via the specific aptamer by self-assembly were used as electrode modifiers for a glassy carbon electrode (aptamer/TiC MXene/GCE). Differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), scanning electron microscopy (SEM), atomic force microscope (AFM), and so on were utilized for electrochemical and morphological characterization.

Blocking BAFF Alleviates Hepatic Fibrosis in -Infected Mice.

Schistosomiasis is an immunopathogenic disease characterized by egg granuloma and fibrosis. The hepatic fibrosis of schistosomiasis is caused by the coordinated action of local immune cells, liver-resident cells and related cytokines around the eggs of the liver. B-cell-activating factor (BAFF), expressed in many cells, is an essential factor for promoting the survival, differentiation, and maturation of cells.

Toward High-Performance Metal-Organic-Framework-Based Quasi-Solid-State Electrolytes: Tunable Structures and Electrochemical Properties.

Metal-organic frameworks (MOFs) have been reported as promising materials for electrochemical applications owing to their tunable porous structures and ion-sieving capability. However, it remains challenging to rationally design MOF-based electrolytes for high-energy lithium batteries. In this work, by combining advanced characterization and modeling tools, a series of nanocrystalline MOFs is designed, and the effects of pore apertures and open metal sites on ion-transport properties and electrochemical stability of MOF quasi-solid-state electrolytes are systematically studied.

Protective effect of wuzibushen recipe on follicular development via regulating androgen receptor in polycystic ovary syndrome model rats.

Objectives: The study aimed to explore the role and mechanism of WZBS recipe on PCOS.

Methods: PCOS model was established. After modeling, PCOS rats were intragastrically administered with Diane-35 or WZBS recipe (6.

Luminescent MOFs constructed by using butterfly-like AIE ligands.

In this work, a series of butterfly-like isomers named oxacalix[2]naphthalene[2]pyrazine (ONP) were conveniently synthesized by a one-step catalyst-free reaction in a facile manner, and they exhibit typical characteristics of aggregation-induced emission (AIE). The mechanism study shows that restriction of intramolecular vibration (RIV) is the reason for their AIE properties. The pyrazine groups endow ONP molecules with good coordination ability, which makes them ideal ligands for constructing metal-organic frameworks (MOFs).

Unravelling the Complex LiOH-Based Cathode Chemistry in Lithium-Oxygen Batteries.

The LiOH-based cathode chemistry has demonstrated potential for high-energy Li-O batteries. However, the understanding of such complex chemistry remains incomplete. Herein, we use the combined experimental methods with ab initio calculations to study LiOH chemistry.

Structural insights into the CP312R protein of the African swine fever virus.

African swine fever (ASF) is a lethal hemorrhagic disease that affects domestic pigs and wild boars. There is no medication available for ASF to date. The ability to mount antigen-specific responses to viral vectored CP312R makes it a crucial potential target for designing vaccines or drugs.

Advances in Lithium-Oxygen Batteries Based on Lithium Hydroxide Formation and Decomposition.

The rechargeable lithium-oxygen (Li-O) batteries have been considered one of the promising energy storage systems owing to their high theoretical energy density. As an alternative to Li-O batteries based on lithium peroxide (LiO) cathode, cycling Li-O batteries the formation and decomposition of lithium hydroxide (LiOH) has demonstrated great potential for the development of practical Li-O batteries. However, the reversibility of LiOH-based cathode chemistry remains unclear at the fundamental level.

Crystal Structure of the Disease-Specific Protein of Rice Stripe Virus.

The rice stripe virus (RSV) is responsible for devastating effects in East Asian rice-producing areas. The disease-specific protein (SP) level in rice plants determines the severity of RSV symptoms. Isothermal titration calorimetry (ITC) and bimolecular fluorescence complementation (BiFC) assays confirmed the interaction between an R3H domain-containing host factor, OsR3H3, and RSV SP and .

Deficiency of PKCλ/ι alleviates the liver pathologic impairment of Schistosoma japonicum infection by thwarting Th2 response.

Background: The activation of immune response driven by the eggs of Schistosoma japonicum and the subsequent secretions is the culprit behind granulomatous inflammation and liver fibrosis. Evidence suggests that PKCλ/ι participates in a variety of physiological and pathological processes, including the regulation of metabolism, growth, proliferation and differentiation of cells. However, the role of PKCλ/ι in liver disease caused by Schistosoma japonicum remains unclear.

Structural insight into African swine fever virus I73R protein reveals it as a Z-DNA binding protein.

African Swine Fever (ASF) is a highly contagious viral haemorrhagic disease of swine, leading to enormous economic losses in the swine industry. However, vaccines and drugs to treat ASF have yet to be developed. African swine fever virus (ASFV) encodes more than 150 proteins, but 50% of them have unknown functions.

Structure-guided rational design of the Geobacillus thermoglucosidasius feruloyl esterase GthFAE to improve its thermostability.

Feruloyl esterases are indispensable biocatalysts catalyzing the cleavage of ester bonds between polysaccharides and their hydroxycinnamoyl cross-links. GthFAE from Geobacillus thermoglucosidasius was identified as a thermophilic alkaline feruloyl esterase with potential applications in paper manufacturing. To improve the enzymatic properties rationally and efficiently, the structure of GthFAE was solved at 1.

In Situ Halogen-Ion Leaching Regulates Multiple Sites on Tandem Catalysts for Efficient CO Electroreduction to C Products.

Tandem catalysts can divide the reaction into distinct steps by local multiple sites and thus are attractive to trigger CO RR to C products. However, the evolution of catalysts generally exists during CO RR, thus a closer investigation of the reconstitution, interplay, and active origin of dual components in tandem catalysts is warranted. Here, taking AgI-CuO as a conceptual tandem catalyst, we uncovered the interaction of two phases during the electrochemical reconstruction.

Roles of ERRα and TGF-β signaling in stemness enhancement induced by 1 µM bisphenol A exposure via human neural stem cells.

Bisphenol A (BPA) is a common industrial chemical widely used to produce various plastics and is known to impair neural stem cells (NSCs). However, the effects of low-dose BPA exposure on the stemness maintenance and differentiation fate of NSCs remain unclear in the infant brain. The present study demonstrated that 1 µM BPA promoted human NSC proliferation and stemness, without significantly increasing apoptosis.

Systematic review and meta-analysis of traditional Chinese medicine compound in treating infertility caused by endometriosis.

Background: To perform meta-analysis to investigate the efficacy and safety of traditional Chinese medicine (TCM) compound in the treatment of endometriosis (EMS)-induced infertility.

Methods: The databases of PubMed, Embase, Cochrane Library, Chinese Journal Full-text Database (CNKI), VIP, Wanfang Science and Technology Journal Full-text Database, and Chinese Biomedical Literature (CBM) were used to search for articles on the treatment of EMS-induced infertility with TCM compound from database establishment to September 2021. Endnote X9 software was used to screen the articles.

Highly dispersed Cr oxygenated species on Pt nanowire assemblies for enhanced electrocatalytic methanol oxidation.

In this paper, Cr oxygenated species dispersed on Pt nanowire assemblies (PtCrO NWs) were successfully prepared for the methanol oxidation reaction by a metal precursor dilution strategy. Notably, the PtCrO NWs catalyst exhibits excellent performance for electrocatalytic methanol oxidation. Density functional theory results revealed that the doped Cr oxygenated species, which moderated the electronic structure of the Pt atoms, can significantly decrease the free energy of COOH* formation, thus leading to superior methanol oxidation performance.