Publications by authors named "Pan-Quan Luo"
Article Synopsis
- Gastric cancer (GC) is a prevalent malignant tumor, and the study investigates the role of CASC19, a new biomarker, in promoting tumor invasion and metastasis via its interaction with miR-491-5p and HMGA2.
- The research involved analyzing clinical samples and various cellular assays to understand how inhibiting CASC19 affects GC cell functions such as proliferation and invasion, as well as to clarify the regulatory relationships between CASC19, miR-491-5p, and HMGA2.
- Results indicated that CASC19 is linked to tumor progression factors, and its knockdown suppresses GC cell growth and promotes apoptosis, while miR-491-5p can inhibit GC cell proliferation and EMT
Article Synopsis
- * It analyzed data from 1,235 patients and identified key independent prognostic factors such as tumor size and specific tumor markers (CEA, CA125, CA19-9).
- * The new score model demonstrated improved predictive accuracy (higher AUC) compared to existing systems, providing a reliable tool for evaluating patient outcomes post-surgery.
Article Synopsis
- The study investigates the significance of post-preoperative tumor markers CEA and CA19-9 in predicting the prognosis of gastric cancer (GC) following surgery, finding their post-operative increments relate to poorer outcomes.* -
- A total of 562 patients who underwent radical gastrectomy were analyzed, revealing that higher increments in these tumor markers after surgery are linked to decreased overall survival rates.* -
- Results indicate that the post-preoperative increments of CEA/CA19-9 are a more reliable prognostic factor than preoperative levels and can improve prognostic models for GC.*
Article Synopsis
- Gastric cancer (GC) has a high incidence and mortality rate globally, prompting the exploration of combining traditional medicines like cryptotanshinone (CTS) with the anti-cancer drug trifluorothymidine (FTD) to improve treatment outcomes.
- The study utilized assays to assess how FTD and CTS affect the growth and apoptosis of GC cells and analyzed specific cell cycle phases, DNA incorporation, and protein expression to determine their mechanisms of action.
- Results revealed that both FTD and CTS inhibited GC cell growth in a dose-dependent manner, with their combination showing a synergistic anticancer effect, particularly by manipulating cell cycle phases and enhancing apoptotic processes in the cells.
Nomogram established using risk factors of early gastric cancer for predicting the lymph node metastasis.
World J Gastrointest Oncol
April 2023
Background: For the prognosis of patients with early gastric cancer (EGC), lymph node metastasis (LNM) plays a crucial role. A thorough and precise evaluation of the patient for LNM is now required.
Aim: To determine the factors influencing LNM and to construct a prediction model of LNM for EGC patients.
Article Synopsis
- Gastric cancer (GC) often leads to recurrence and peritoneal dissemination even after surgical resection, making it crucial to remove residual cancer cells during surgery.
- A study evaluated the long-term effects of extensive intraoperative peritoneal lavage (EIPL) combined with chemotherapy in 150 patients with advanced GC, comparing outcomes with a standard procedure.
- Results showed that patients who underwent EIPL had better overall survival rates (71.0% at 1 year and 26.5% at 3 years) and fewer complications compared to those who had standard lavage, highlighting EIPL as an important prognostic factor.
Background: Nearly 66% of occurrences of gastric cancer (GC), which has the second-highest death rate of all cancers, arise in developing countries. In several cancers, the predictive significance of inflammatory markers has been established.
Aim: To identify clinical characteristics and develop a specific nomogram to determine overall survival for GC patients.
Background: Hepatocellular carcinoma (HCC) is the most common type of liver cancer and has a high risk of invasion and metastasis along with a poor prognosis.
Aim: To investigate the independent predictive markers for disease-free survival (DFS) in patients with HCC and establish a trustworthy nomogram.
Methods: In this study, 445 patients who were hospitalized in The First Affiliated Hospital of Anhui Medical College between December 2009 and December 2014 were retrospectively examined.
Background: In recent years, the incidence of types II and III adenocarcinoma of the esophagogastric junction (AEG) has shown an obvious upward trend worldwide. The prognostic prediction after radical resection of AEG has not been well established.
Aim: To establish a prognostic model for AEG (types II and III) based on routine markers.
Background: The prognosis of patients with hepatocellular carcinoma (HCC) remains difficult to accurately predict. The purpose of this study was to establish a prognostic model for HCC based on a novel scoring system.
Methods: Five hundred and sixty patients who underwent a curative hepatectomy for treatment of HCC at our hospital between January 2007 and January 2014 were included in this study.