Planar tetracoordinate beryllium in σ-aromatic Li4Be and Na4Be clusters: A missing member in first-octal row planar tetracoordinate family.

While planar tetracoordinate (pt) centers have been extensively explored from carbon to other octal-row elements or their heavier analogs, their counterparts involving alkali (A) and alkaline-earth metals (Ae) remain elusive due to the large atomic radius and absence of p orbitals. In this work, we found six hitherto unknown anionic ptA (A4A-) and neutral ptAe (A4Ae) centers through an extensive exploration of potential energy surfaces. The D4h-symmetry ptBe structures in Li4Be and Na4Be emerge as the lowest-energy configurations, and all the other ptA/ptAe structures are higher in energy or saddle points.

Identification of circulating risk biomarkers for cognitive decline in a large community-based population in Chongqing China.

Introduction: This study aims to investigate the relationship between blood-based pathologies and established risk factors for cognitive decline in the community-based population of Chongqing, a region with significant aging.

Methods: A total of 26,554 residents aged 50 years and older were recruited. Multinomial logistic regression models were applied to assess the risk factors of cognition levels.

Solar-Driven Sulfide Oxidation Paired With CO Reduction Based on Vacancies Engineering of Copper Selenide.

Photovoltaic-driven electrochemical (PV-EC) carbon dioxide reduction (COR) coupled with sulfide oxidation (SOR) can efficiently convert the solar energy into chemical energy, expanding its applications. However, developing low-cost electrocatalysts that exhibit high selectivity and efficiency for both COR and SOR remains a challenge. Herein, a bifunctional copper selenide catalyst is developed with copper vacancies (v-CuSe) for the COR-SOR.

Emergent Mid-Infrared Nonlinear Optical Candidates With Targeted Balance Performances.

Infrared nonlinear optical (NLO) crystal materials exert a crucial role in laser technology, which is extensively utilized in the fields of medical laser, long-distance laser communication, infrared laser guidance, etc. Currently, the commercially available infrared NLO crystals are diamond-like structural crystals AgGaQ (Q = S, Se) and ZnGeP. However, their applications are significantly limited owing to their inherent drawbacks, such as low laser damage thresholds and narrow band gaps.

[Changes and correlation between serum β-amyloid 1-42 and total bilirubin in patients with Alzheimer's disease].

To investigate the levels of β-amyloid 1-42 (Aβ1-42) and total bilirubin (TBIL) in serum of patients with Alzheimer 's disease (AD) and the relationship between them. A case-control study was conducted to select 73 patients with AD who were hospitalized in Beijing Huilongguan Hospital from November 2023 to February 2024 as AD group, and 70 healthy controls (HC) were selected as HC group. The basic information of all subjects and the clinical information of AD patients were collected, and the levels of Aβ1-42 and TBIL were detected and compared between the two groups.

Effects of Canagliflozin Preconditioning on Post-resuscitation Myocardial Function in a Diabetic Rat Model of Cardiac Arrest and Cardiopulmonary Resuscitation.

Background: Canagliflozin can reduce the risk of cardiovascular disease in patients except for its targeted antidiabetic effects. However, it remains unknown whether canagliflozin alleviates the post-resuscitation myocardial dysfunction (PRMD) in type 2 diabetes mellitus.

Objective: To explore the effects and potential mechanisms of canagliflozin on myocardial function after cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) in a type 2 diabetic rat model.

CRISPR-Cas12a2-based rapid and sensitive detection system for target nucleic acid.

Infectious diseases are extremely important public health issues, where the design of effective, rapid, and convenient detection platforms is critical. In this study, we coupled SuCas12a2, a novel Cas12 family RNA-targeting nuclease, with conventional PCR and recombinase polymerase amplification (RPA), respectively, to develop novel detection approaches, named PCR-SuCas12a2 and RPA-SuCas12a2. SuCas12a2 possesses collateral cleavage activity and cuts the additional single-stranded RNA (ssRNA) added to the reaction system once the ternary complex RNA-SuCas12a2-CRISPR RNA (crRNA) is formed.

Dual-ligand engineered CoNi alloy/N-doped carbon nanotubes bifunctional ORR/OER electrocatalyst for long-lifespan rechargeable Zn-air batteries.

The development of carbon-encapsulated alloy catalysts, through a rational design that integrates highly active Me-N-C sites, is essential for improving the reaction kinetics of both oxygen reduction (ORR) and oxygen evolution reactions (OER). This advancement is pivotal for the progression of efficient rechargeable zinc-air batteries (RZABs). In this study, we investigates a CoNi alloy decorated N-doped carbon nanotube (CoNi-NCNT) electrocatalyst using a dual-ligand strategy.

Antioxidants in neuropsychiatric disorder prevention: neuroprotection, synaptic regulation, microglia modulation, and neurotrophic effects.

Oxidative stress, caused by an imbalance between the generation of reactive oxygen species (ROS) and the body's intrinsic antioxidant defenses, plays a critical role in neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. Beyond these conditions, recent evidence indicates that dysregulated redox balance is implicated in neuropsychiatric disorders, including schizophrenia, major depressive disorder, and anxiety disorders. Preclinical and clinical studies have demonstrated the potential of antioxidants, such as N-acetylcysteine, sulforaphane, alpha-lipoic acid, L-carnitine, ascorbic acid, selenocompounds, flavones and zinc, in alleviating neuropsychiatric symptoms by mitigating excitotoxicity, enhancing synaptic plasticity, reducing microglial overactivation and promoting synaptogenesis.

Boosting Photovoltaic Efficiency: The Role of Functional Group Distribution in Perovskite Film Passivation.

The utilization of small organic molecules with appropriate functional groups and geometric configurations for surface passivation is essential for achieving efficient and stable perovskite solar cells (PSCs). In this study, two isomers, 4-sulfonamidobenzoic acid (4-SA) and 3-sulfamobenzoic acid (3-SA), both featuring sulfanilamide and carboxyl functional groups arranged in different positions, are evaluated for their effectiveness in passivating defects of the perovskite layer. The calculation and characterization results reveal that 3-SA, with its meta-substitution, offered superior passivation compared to the para-substituted 4-SA, leading to enhanced charge carrier dynamics and extraction efficiency.

Precooling storage of bone cement in percutaneous vertebroplasty for osteoporotic vertebral compression fracture.

Purpose: This study aimed to investigate the effect of precooling storage of bone cement in percutaneous vertebroplasty(PVP) for the patients with osteoporotic vertebral compression fracture (OVCF).

Methods: A total of 207 OVCF patients who underwent PVP were included in this study. Two different storage methods for the bone cement were randomly utilized: an operating room (NT group, 23 °C) and a refrigerator (PC group, 4 °C).

Standardized Assessment of Energy Excretion in Healthy Adults: A Novel Methodology.

Background: Accurate monitoring of energy balance is essential for effective weight management, but the role of energy excretion is often neglected.

Objective: This study aimed to develop and validate a standardized method for assessing energy excretion using dye-labeled meal replacement bars with consistent and stable ingredients.

Methods: We utilized baseline data from a registered cross-over trial involving twelve healthy adults (7 females, 5 males) with a body mass index of 18-25 kg/m.

Hydrogeochemical mechanism of Li-Cs-rich thermal springs in the Karakoram Fault, Qinghai-Xizang Plateau: New insights from multiple stable isotopes.

High lithium (Li) and cesium (Cs) concentrations in the Qinghai-Xizang Plateau thermal springs pose environmental and health challenges, but their origins and enrichment mechanisms remain unclear. This study focuses on the Sogdoi geothermal field, located along the southern Karakoram Fault, to investigate these processes. Multi-isotope analyses (H, O, Li, Sr) reveal that Li and Cs predominantly originate from the host rocks, especially granitoids and meta-sedimentary rocks, rather than from magmatic fluids.

Temporal trends in gender, etiology, severity and outcomes of acute pancreatitis in a third-tier Chinese city from 2013 to 2021.

Background: To evaluate temporal trends in gender, etiology, severity, outcomes, cost and median length of stay (MLS) in patients with acute pancreatitis (AP) in a third-tier Chinese city.

Methods: Patients with AP admitted to a university hospital between January 2013 and December 2021. Relationships between etiology, prevalence of severe acute pancreatitis (SAP) and survey years were investigated by joinpoint regression analysis.

The impact of working night shifts on cardiac autonomic nervous regulation during the six-minute walk test in nurses.

Background: Clinical nurses frequently face the necessity of working night shifts, often with insufficient opportunities for timely sleep recovery, which may negatively impact autonomic nervous system regulation. The aim of this study was to evaluate changes in heart rate variability (HRV) after the six-minute walk test (6MWT) in nurses post-night shift and to explore the impact of night shift work on cardiac autonomic regulation.

Methods: Thirty-five female nurses, with a mean age of 28.

Maternal group B decreases infant length and alters the early-life microbiome: a prospective cohort study.

Background: Maternal colonization with Group B Streptococcus (GBS) disrupts the vaginal microbiota, potentially affecting infant microbiota assembly and growth. While the gut microbiota's importance in infant growth is recognized, the specific effects of maternal GBS on growth remain unclear. This study aimed to explore the effects of maternal vaginal GBS during pregnancy on early infant growth, microbiome, and metabolomics.

CBC With Differential and Cell Population Data in Prediction of Fever With Thrombocytopenia Syndrome.

Introduction: We aimed to identify additional predictors of severe fever with thrombocytopenia syndrome (SFTS), which has a significantly increasing global incidence.

Methods: This retrospective study included 95 patients with SFTS and 30 healthy individuals. Complete blood count with differential was performed using Sysmex XN 9000 and Mindray BC-6800 Plus analyzers.

Dynamic Liquid Metal-Microfiber Interlocking Enables Highly Conductive and Strain-insensitive Metastructured Fibers for Wearable Electronics.

Stretchable fibers with high conductivity are vital components for smart textiles and wearable electronics. However, embedding solid conductive materials in polymers significantly reduces conductive pathways when stretched, causing a sharp drop in conductivity. Here, a stretchable metastructured fiber with dynamic liquid metal-microfiber interlocking interface is reported to realize highly conductive yet ultrastable conductance.

Role of ubiquitin-proteasome pathway in budded virus egress and GP64 surface distribution in Bombyx mori nucleopolyhedrovirus.

The Bombyx mori nucleopolyhedrovirus (BmNPV) is a DNA virus that affects the silkworm, , causing substantial economic losses in sericulture. This study investigates the mechanisms underlying budded virus egress, focusing on the roles of the ubiquitin-proteasome pathway (UPP) machinery. BmNPV produces two virion types: budded virions (BVs) and occlusion-derived virions (ODVs), which differ in their envelope origins and functions.

Physician-clinical coder collaboration effectively improves coding accuracy: A single-centre prospective study in China.

Clinical coding is important for reimbursement, resource planning, administration and medical research. This study aimed to evaluate clinical coding accuracy and its influencing factors, especially the benefits of physician-clinical coder collaboration. Twenty-four physicians and one senior clinical coder participated in the quality audit.

Primary intracranial neuroendocrine tumor at the sphenoid ridge with metastasis to the spinal cord: A case report.

Rationale: Neuroendocrine tumors (NETs) originate from neuroendocrine cells and they are depicted with both nerve cells as well as hormone-producing cells. These tumors were initially discovered in extracranial locations and central nervous system involvement is often a result of metastasis. Herein, we present a very rare case of primary intracranial neuroendocrine tumor (PINET) that masqueraded as meningioma at the sphenoid ridge with metastasis to the spinal cord in a patient without a known history of extracranial NET at the time of diagnosis.

Prescription Design of Sinomenine Gel Based on Molecular Dynamics Simulations.

Sinomenine (SIN) is a drug for the treatment of rheumatoid arthritis, most of which is administered orally, but it is prone to adverse gastrointestinal effects. Gel can overcome the gastrointestinal adverse effects caused by oral administration. In this paper, a multiscale computational pharmaceutics strategy was developed to guide the systematic study of formulation factors of a SIN gel and, further, to guide the formulation design.

High-Sensitivity, High-Resolution Miniaturized Spectrometers for Ultraviolet to Near-Infrared Using Guided-Mode Resonance Filters.

Miniaturized spectrometers have significantly advanced real-time analytical capabilities in fields such as environmental monitoring, healthcare diagnostics, and industrial quality control by enabling precise on-site spectral analysis. However, achieving high sensitivity and spectral resolution within compact devices remains a significant challenge, particularly when detecting low-concentration analytes or subtle spectral variations critical for chemical and molecular analysis. This study introduces an innovative approach employing guided-mode resonance filters (GMRFs) to address these limitations.

Deciphering Oxidation-Dominated Abnormal Rheology to Design Performance-Stable Liquid-Metal-Based Nanofluids for Transmission Applications.

With global decarbonization urgency for sustainability, enhancing the service stability of liquid metals (LMs) and reducing their oxidation-induced failures are crucial. The oxidation of LMs can adversely affect the fluidity required for hydraulic transmission, thermal management, and other transport scenarios. Given the importance, we have fabricated an LM-based SiC/graphene-Mo nanofluid (LMNF) and compared the rheological behavior to pure LM under an oxidative atmospheric environment.

Adaptive memory reservation strategy for heavy workloads in the Spark environment.

The rise of the Internet of Things (IoT) and Industry 2.0 has spurred a growing need for extensive data computing, and Spark emerged as a promising Big Data platform, attributed to its distributed in-memory computing capabilities. However, practical heavy workloads often lead to memory bottleneck issues in the Spark platform.