Analysis of factors affecting long-term quality of life in children on home mechanical ventilation: a 4-year prospective observational cohort study.

Background: Home mechanical ventilation improves survival of critically ill children but partially affects quality of life. Studies in China have more often analyzed the risk factors for death from prolonged mechanical ventilation in hospitalized children while less attention has been paid to children with home mechanical ventilation. This study aimed to describe the quality of life of children with home mechanical ventilation and the influencing factors.

The Compensatory Effect of S375F on S371F Is Vital for Maintaining the Infectivity of SARS-CoV-2 Omicron Variants.

The emergence of Omicron variants dramatically changed the transmission rate and infection characteristics compared to previously prevalent strains, primarily due to spike protein mutations. However, the impact of individual mutations remained unclear. Here, we used virus-like particle (VLP) pseudotyped to investigate the functional contributions by 12 common mutations in the spike protein.

Epigenetic targets and their inhibitors in the treatment of idiopathic pulmonary fibrosis.

Idiopathic pulmonary fibrosis (IPF) is a deadly lung disease characterized by fibroblast proliferation, excessive extracellular matrix buildup, inflammation, and tissue damage, resulting in respiratory failure and death. Recent studies suggest that impaired interactions among epithelial, mesenchymal, immune, and endothelial cells play a key role in IPF development. Advances in bioinformatics have also linked epigenetics, which bridges gene expression and environmental factors, to IPF.

Femtosecond Laser Opening Hierarchical Lamination: Micro-Nano Hybrid Scissoring of Three-Dimensional Nitrogen-Doped Graphene for Solar Steam Generation.

Three-dimensional (3D) nanoporous nitrogen-doped graphene is an ideal candidate for solar steam generation. However, the outermost dense layer formed during high-temperature thermal chemical vapor deposition (CVD) severely blocks water transport and steam escape. In this work, a technique of femtosecond laser opening hierarchical lamination (FLOHL) enabling hierarchical micro-nano hybrid scissoring of graphene is presented for its structural and performance upgrades.

ITGB1/FERMT1 mechanoactivation enhances CD44 characteristic stemness in oral squamous cell carcinoma via ubiquitin-dependent CK1α degradation.

Cancer stem cells (CSCs) contribute to chemotherapy resistance and poor prognosis, posing significant challenges in the treatment of oral squamous cell carcinoma. The extracellular matrix (ECM)-constructed microenvironment remodels the niche of CSCs. Yet mechanisms by which biophysical properties of ECM relate to CSCs remain undefined.

Progressive Semantic Enhancement Network for Hyperspectral and LiDAR Classification.

The joint classification of hyperspectral image (HSI) and light detection and ranging (LiDAR) data is gaining attention for its improved classification accuracy. However, effectively integrating the rich spectral information of HSI and the elevation features of LiDAR has remained a challenge in multimodal fusion. This article proposes a novel approach called progressive semantic enhancement network (PSENet) for hyperspectral and LiDAR classification based on a progressive joint spatial-spectral attention mechanism.

Impact of self-efficacy and burnout on professional development of physical education teachers in the digital age: a systematic review.

Background: The professional development of teachers in the digital age will positively impact the effectiveness of physical education teaching. Exploring key factors such as self-efficacy, burnout, and digital technology is crucial to ensure the professional development of teachers.

Methods: The search was conducted in accordance with the PRISMA guidelines and utilized the following databases: Scopus, Web of Science, ProQuest, and Google Scholar.

Correlation between gut microbiota and tumor immune microenvironment: A bibliometric and visualized study.

Background: In recent years, numerous reports have been published regarding the relationship between the gut microbiota and the tumor immune microenvironment (TIME). However, to date, no systematic study has been conducted on the relationship between gut microbiota and the TIME using bibliometric methods.

Aim: To describe the current global research status on the correlation between gut microbiota and the TIME, and to identify the most influential countries, research institutions, researchers, and research hotspots related to this topic.

Effects of organophosphate esters on thyroid function during pregnancy: Risk of endocrine disruptors during early- and mid-pregnancy.

Organophosphate esters (OPEs) can disrupt thyroid function, but the association between OPEs and thyroid function is limited. In this study, the association between OPEs and thyroid hormones (THs) was studied. The study population was comprised of two groups: early-pregnancy and mid-pregnancy.

Identification of biomarkers and mechanism exploration of ferroptosis related genes regulated by m6A in type 2 diabetes mellitus.

Purpose: This study is aims to explore the role of ferroptosis genes regulated by N6-methyladenosine (m6A) in Type 2 diabetes mellitus (T2DM).

Material And Methods: Firstly, differentially expressed m6A-FRGs (DEm6A-FRGs) were obtained by intersecting the differentially expressed genes (DEGs) and the m6A-related ferroptosis genes (m6A-FRGs). After enrichment analysis of DEm6A-FRGs, artificial neural network (ANN) and nomogram models were constructed using 4 biomarkers.

Krill oil for knee osteoarthritis: A meta-analysis of randomized controlled trials.

Background: Knee osteoarthritis, a prevalent musculoskeletal disorder, significantly impacts global health and quality of life. Unfortunately, there is no disease modifying osteoarthritis drugs until now. Krill oil is being explored as a potential alternative, however its efficacy in managing knee symptoms remains unclear.

Prevalence and sociodemographic characteristics of functional impairment in community-dwelling older adults in China: a cross-sectional study.

Objectives: Functional impairment is an early stage of disability, and timely identification and intervention are critical for the health of older adults. However, little is known about the functional impairment of Chinese older adults due to the absence of specialised assessment tools. This study aimed to explore the prevalence and socio-demographic characteristics of functional impairment in Chinese community-dwelling older adults using the Function Impairment Screening Tool (FIST), which was previously developed based on the Delphi method.

Change surface regression for nonlinear subgroup identification with application to warfarin pharmacogenomics data.

Pharmacogenomics stands as a pivotal driver toward personalized medicine, aiming to optimize drug efficacy while minimizing adverse effects by uncovering the impact of genetic variations on inter-individual outcome variability. Despite its promise, the intricate landscape of drug metabolism introduces complexity, where the correlation between drug response and genes can be shaped by numerous nongenetic factors, often exhibiting heterogeneity across diverse subpopulations. This challenge is particularly pronounced in datasets such as the International Warfarin Pharmacogenetic Consortium (IWPC), which encompasses diverse patient information from multiple nations.

Late positive potentials elicited by negative self-referential processing predict increases in social anxiety, but not depressive, symptoms from age 11 to age 12.

Social anxiety and depression exacerbate in early adolescence. Maladaptive self-referential processing confers risk for both conditions and can be assessed by the Self-Referent Encoding Task (SRET). Our cross-sectional findings indicated that the SRET-elicited anterior late positive potential (LPP) was uniquely associated with social anxiety symptoms, whereas behavioral SRET scores were uniquely associated with depressive symptoms.

Nomogram for Predicting 90-day Outcomes in Patients with Acute Vertebrobasilar Artery Occlusion Undergoing Endovascular Treatment: A Multicenter Cohort Study.

Background And Purpose: In this study, we aimed to develop and validate a novel nomogram model for predicting 90-day non-favorable clinical outcomes in patients with acute vertebrobasilar artery occlusion after endovascular treatment by integrating clinical and MRI features.

Materials And Methods: This multicenter retrospective study analyzed data from 181 patients with vertebrobasilar artery occlusion eligible for endovascular treatment from two Chinese stroke centers. We developed a predictive model for non-favorable clinical outcomes (modified Rankin Scale score >3) using the data of 125 patients from Stroke Center A (2019-2023).

Age and anxiety symptoms jointly moderated the curvilinear changes in trial-level ERN following repeated errors on a Go/No-Go task during early adolescence.

The ability to detect and monitor errors enables us to maintain optimal performance across tasks. One neurophysiological index of error monitoring is the error-related negativity (ERN), a fronto-central negative deflection peaking between 0 and 150 ms following an erroneous response. While the developmental literature has illustrated age-related differences in the ERN and its association with anxiety, the literature has mainly focused on the between-person differences of the ERN.

Technological advances in clinical individualized medication for cancer therapy: from genes to whole organism.

Efforts have been made to leverage technology to accurately identify tumor characteristics and predict how each cancer patient may respond to medications. This involves collecting data from various sources such as genomic data, histological information, functional drug profiling, and drug metabolism using techniques like polymerase chain reaction, sanger sequencing, next-generation sequencing, fluorescence in situ hybridization, immunohistochemistry staining, patient-derived tumor xenograft models, patient-derived organoid models, and therapeutic drug monitoring. The utilization of diverse detection technologies in clinical practice has made "individualized treatment" possible, but the desired level of accuracy has not been fully attained yet.

Transmantle pressure under the influence of free breathing: non-invasive quantification of the aqueduct pressure gradient in healthy adults.

Background: The pressure gradient between the ventricles and the subarachnoid space (transmantle pressure) is crucial for understanding CSF circulation and the pathogenesis of certain neurodegenerative diseases. This pressure can be approximated by the pressure difference across the aqueduct (ΔP). Currently, no dedicated platform exists for quantifying ΔP, and no research has been conducted on the impact of breathing on ΔP.

Cardiac and respiratory activities induce temporal changes in cerebral blood volume, balanced by a mirror CSF volume displacement in the spinal canal.

Understanding cerebrospinal fluid (CSF) dynamics is crucial for elucidating the pathogenesis and diagnosis of neurodegenerative diseases. The primary mechanisms driving CSF oscillations remain a topic of debate. This study investigates whether cerebral blood volume displacement (CBV), modulated by breathing and cardiac activity, is the predominant drivers of CSF oscillations.

Recent advances in the treatment of non-small cell lung cancer with MET inhibitors.

Recently, research into the oncogenic driver genes associated with non-small cell lung cancer (NSCLC) has advanced significantly, leading to the development and clinical application of an increasing number of approved therapeutic agents. Among these, small molecule inhibitors that target mesenchymal-epithelial transition (MET) have demonstrated successful application in clinical settings. Currently, three categories of small molecule MET inhibitors, characterized by distinct binding patterns to the MET kinase region, have been developed: types Ia/Ib, II, and III.

Bacteriophage diversity and novelty revealed by metaviromic analysis of the gut virome in the medicinal Blaps rynchopetera.

The medicinal beetle Blaps rynchopetera is recognized for its antibacterial, anti-inflammatory, and immune-regulating properties. This study utilized metaviromics technology to systematically characterize the viral community within the gut of B. rynchopetera through high-throughput sequencing of gut contents, with a specific focus on the composition of its bacteriophage community.

Efficacy and safety of quadriceps tendon autograft versus bone-patellar tendon-bone and hamstring tendon autografts for anterior cruciate ligament reconstruction: a systematic review and meta-analysis.

Background: Quadriceps tendon (QT), bone-patellar tendon-bone (BPTB), and hamstring tendon (HT) autografts are widely used for anterior cruciate ligament reconstruction (ACLR), but the optimal autograft choice remains controversial. This study assessed the treatment effects of QT versus BPTB and HT autografts for ACLR.

Methods: The PubMed, Embase, and Cochrane Library databases were systematically searched for eligible studies published from inception until July 2022.