Publications by authors named "Pan Kai-Su"
Background: The use of fluconazole for long-term oral candidiasis treatment in HIV/AIDS patients can potentially affect the clearance rate and antifungal efficacy of voriconazole against Talaromyces marneffei infection. We isolated two T. marneffei strains that were both resistant to fluconazole and voriconazole.
View Article and Find Full Text PDFThe diagnosis of Talaromyces marneffei infection in HIV-negative patients remains challenging. There is an urgent need for rapid and convenient methods to diagnose this complicated disease. The aim of this study was to evaluate the diagnostic efficiency of metagenomic next-generation sequencing (mNGS) for talaromycosis in non-HIV-infected patients by comparing mNGS with traditional microbial culture.
View Article and Find Full Text PDFBackground: Mucormycosis is a rare form of invasive, rapidly progressive and lethal opportunistic fungal infection caused by Mucorales. Although Rhizopus arrhizus (R. arrhizus) is the most commonly isolated Mucorales worldwide, infections caused by Apophysomyces variabilis (A.
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- A thermally dimorphic fungus causes systemic mycoses and the study focuses on the combined use of berberine (BBR) and fluconazole (FLC) against FLC-resistant strains.
- The combination of BBR and FLC significantly lowers the minimum inhibitory concentration (MIC) from 256 μg/ml to 8 μg/ml, indicating a strong synergistic effect.
- Mechanisms behind the antifungal action include increased reactive oxygen species, reduced ergosterol content, disrupted cell integrity, and reduced expression of specific genes, suggesting BBR could effectively treat Talaromycosis.
Article Synopsis
- Increasing reports of phaeohyphomycosis in both animals and humans raise concerns as the pathogenesis and virulence of the implicated fungus remain underexplored.
- Experimental studies on BALB/c mice showed that different inoculation routes led to skin lesions and confirmed infection through mycological and histopathological methods.
- Voriconazole was found to be the most effective antifungal treatment against the fungus, while fluconazole showed the least effectiveness, indicating a need for further research into its pathogenicity.
This study analyzed the drug sensitivity of spp. from Guangxi, Southern China. One hundred three strains of were recovered from 86 patients; 14 were HIV positive and 72 were HIV negative.
View Article and Find Full Text PDFTalaromyces marneffei causes life-threatening opportunistic infections, mainly in Southeast Asia and South China. T. marneffei mainly infects patients with human immunodeficiency virus (HIV) but also infects individuals without known immunosuppression.
View Article and Find Full Text PDFis a common cause of infection in immunocompromised patients in Southeast Asia and Southern China. The pathogenicity of depends on the ability of the fungus to survive the cytotoxic processes of the host immune system and grow inside host macrophages. These mechanisms that allow to survive macrophage-induced death are poorly understood.
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- Limited knowledge exists about Talaromyces marneffei infection in children, prompting a retrospective study involving 11 HIV-negative pediatric patients.
- The study revealed a mortality rate of 36.36%, with many children having underlying diseases and significant immune system issues.
- Voriconazole was the primary treatment, showing positive results in most cases, while also highlighting the importance of recognizing this infection as a sign of severe immunodeficiencies in children.
Talaromyces (Penicillium) marneffei can cause fatal disseminated infection in immunocompromised hosts. However, therapeutic strategies for the mycosis are limited. Reports of the other fungi suggest that berberine, a component of traditional herb, inhibitors interact with antifungal agents to improve the treatment outcomes.
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