Publications by authors named "Pamudika Kiridena"
Article Synopsis
- The paternal environment before conception can affect the physiology and behavior of offspring, with changes in the sperm epigenome playing a key role in non-genetic inheritance.
- A study on male mice showed that depleting their gut microbiome with antibiotics led to their offspring having lower body weight, altered gut morphology, and significant changes in emotional behaviors like anxiety and depression.
- The research identified that gut microbiome depletion affected the expression of specific small RNAs in sperm, suggesting that paternal gut health influences epigenetic inheritance and could have implications for other species, including humans.
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a clear genetic component. While most SLE patients carry rare gene variants in lupus risk genes, little is known about their contribution to disease pathogenesis. Amongst them, SH2B3-a negative regulator of cytokine and growth factor receptor signaling-harbors rare coding variants in over 5% of SLE patients.
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