Molecular dynamics directed neuroprotective activity of alcoholic extract of Garuga pinnata Roxb. in experimental rats.

Background: Garuga pinnata Roxb., a member of family Burseraceae, is a commonly grown plant in south east Asia including India in tropical rain forests predominately. Apart from folkloric use, important anti-inflammatory and antiasthamatic activity of this plant has been revealed.

Self Nanoemulsifying Drug Delivery System of Sorafenib Tosylate: Development and Studies.

Background: Sorafenib tosylate (SFN) belongs to the BCS class II drug with low solubility and undergoes first-pass metabolism, which leads to reduced bioavailability of 38%.

Objective: The present study aimed at developing SFN SNEDDS to improve their solubility and bioavailability.

Methods: Preliminary solubility studies were performed to identify oil, surfactant, and co-surfactant ratios.