Maternal exposure to soy diet reduces atheroma in hyperlipidemic F1 offspring mice by promoting macrophage and T cell anti-inflammatory responses.

Background And Aims: Maternal hypercholesterolemia has been implicated in earlier onset of atherosclerotic lesions in neonatal offspring. In this study, we investigated whether maternal exposure to soy protein isolate (SPI) diet attenuated the progression of atherosclerosis in F1 offspring.

Method: Pregnant apolipoprotein E knockout (Apoe) female mice were fed SPI diet until postnatal day 21 (PND21) of the offspring (SPI-offspring).