Publications by authors named "Pamela Y Rodriguez-Ordonez"
Article Synopsis
- Donor kidneys experience changes in macrophage behavior after ischemia-reperfusion injury, impacting their inflammatory and reparative functions in transplantation.
- Cold ischemia and reversible injury reduce the ability of renal macrophages to present antigens and shift them towards a pro-repair M phenotype while increasing IL-1R8 expression.
- IL-1R8 plays a critical role in regulating macrophage functions post-injury, influencing immune responses and tissue repair, suggesting it could be a potential target for improving transplant outcomes.
Background: Tissue fibrosis is the final common phase of chronic allograft injury, the leading cause of late graft loss in kidney transplantation. Preclinical evidence points to the involvement of lysophosphatidic acid (LPA), a bioactive phospholipid, in the development of renal fibrosis.
Objectives: We assessed whether treatment with an orally available inhibitor of autotaxin (ATXi), the main LPA-producing enzyme, could slow the progression of chronic allograft injury in a fully major histocompatibility complex-mismatched rat kidney transplant model and compared its effects with those of the angiotensin-converting enzyme inhibitor lisinopril.
Background: The rat orthotopic lung transplant model is not widely used yet because of the complexity of the procedure, in particular, venous anastomosis. Here, we performed a rat orthotopic lung transplantation using either the suture (ST) or cuff (CT) method for vein anastomosis.
Objectives: To compare the vein ST and CT techniques in terms of operative time, success, recipient survival, and early histological outcomes was the objective of this study.