Publications by authors named "Pamela Wat"
Article Synopsis
- Patient-derived samples offer a more reliable model for studying high-grade serous ovarian cancer (HGSOC) compared to traditional cell line models, as they accurately reflect the in vivo characteristics of the disease.
- Researchers characterized patient-derived xenograft (PDX) models, discovering that samples exhibited a hybrid of epithelial and mesenchymal traits, impacting their self-renewal and tumorigenicity.
- A notable finding was the inverse relationship between let-7 microRNA and stemness, suggesting that lower let-7 levels correlate with greater tumorigenic potential and sensitivity to chemotherapy, while also indicating that stemness and invasiveness can be dissociated in HGSOC cells.
