Sustained activation of the Ca-release-activated Ca (CRAC) channel is pivotal for effector T cell responses. The mechanisms underlying this sustainability remain poorly understood. We find that plasma membrane localization of ORAI1, the pore subunit of CRAC channels, is limited in effector T cells, with a significant fraction trapped in intracellular vesicles.
View Article and Find Full Text PDFBMJ Open Diabetes Res Care
July 2017
Objective: To determine prevalence and factors predictive of periodontitis by using a standardized assessment model in adults with type 2 diabetes.
Research Design And Methods: We performed an observational cross-sectional study to determine the burden of periodontitis in adults with type 2 diabetes attending urban, ambulatory referral centers in the USA and UK. Full-mouth probing was performed and periodontitis was diagnosed based on either a low (≥5 mm at ≥1 site) or high pocket probing-depth threshold (≥6 mm at ≥1 site).
© LitMetric 2025. All rights reserved.