Publications by authors named "Pamela Stratton"

Article Synopsis
  • - Patients with GATA2 haploinsufficiency face higher risks for HPV-related anogenital cancers, with the study showing that HPV appeared at a median age of 18.9 in females and 25.6 in males, often leading to significant health issues.
  • - The research conducted a thorough review of 68 patients over 17 years, revealing that 76% had HPV-related squamous intraepithelial lesions (SIL), with females showing a higher prevalence and severity of high-grade lesions compared to males.
  • - Among patients receiving hematopoietic stem cell transplants for GATA2-linked diseases, some still experienced persistent HPV issues post-treatment; however, those who received vaccinations afterward showed minimal evidence
View Article and Find Full Text PDF

Importance: Evidence suggests that aberrant uterine contractility in nonpregnant women with endometriosis and adenomyosis contributes to symptoms and potentially heralds their pathogenesis. However, uterine peristalsis remains understudied, inconsistently measured, and poorly understood.

Objective: To summarize evidence on uterine contractility across the menstrual cycle phases in women with endometriosis and adenomyosis.

View Article and Find Full Text PDF
Article Synopsis
  • Fanconi anemia (FA), dyskeratosis congenita-related telomere biology disorders (DC/TBD), and Diamond-Blackfan anemia (DBA) are inherited conditions that significantly increase the risk of bone marrow failure and related cancers.
  • The study found that males with FA and DC/TBD had significantly lower serum levels of anti-Müllerian hormone (AMH), a marker for fertility, compared to unaffected relatives and healthy males.
  • These results suggest that there might be a defect in AMH production in postpubertal males with FA and DC/TBD, indicating potential fertility issues similar to those seen in females; further research is needed to confirm these findings.
View Article and Find Full Text PDF
Article Synopsis
  • Botulinum toxin (BoNT) injections for chronic pelvic pain can be painful, but applying mindfulness techniques may help reduce associated anxiety and pain.
  • A clinical trial involving women with endometriosis-associated pelvic pain included mindfulness sessions before and/or after the injections.
  • Results showed significant reductions in anxiety, pain, and dysphoria after mindfulness sessions, suggesting they can improve the tolerability of the procedure.
View Article and Find Full Text PDF

Objective: The World Endometriosis Research Foundation established the Endometriosis Phenome and Biobanking Harmonisation Project (EPHect) to create standardized documentation tools (with common data elements) to facilitate the comparison and combination of data across different research sites and studies. In 2014, 4 data research standards were published: clinician-reported surgical data, patient-reported clinical data, and fluid and tissue biospecimen collection. Our current objective is to create an EPHect standard for the clinician-reported physical examination (EPHect-PE) for research studies.

View Article and Find Full Text PDF

A female proband and her affected niece are homozygous for a novel frameshift variant of CLPP. The proband was diagnosed with severe Perrault syndrome encompassing hearing loss, primary ovarian insufficiency, abnormal brain white matter and developmental delay.

View Article and Find Full Text PDF
Article Synopsis
  • - The study aims to create a standardized set of patient-centered outcomes for treating endometriosis, enhancing personalized care and monitoring treatment effectiveness.
  • - Using a modified Delphi method, 51 participants from 16 countries evaluated numerous Patient Reported Outcome Measures (PROMs) and Clinician Reported Outcome Measures (CROMs) to establish relevant metrics for routine care.
  • - The final outcomes include six PROMs focused on symptoms, pain, productivity, and quality of life, alongside ten CROMs covering clinical indicators; additional tools are also suggested for assessing psychological and sexual impacts of endometriosis.
View Article and Find Full Text PDF

BACKGROUNDWarts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome is a primary immunodeficiency disorder caused by heterozygous gain-of-function CXCR4 mutations. Myelokathexis is a kind of neutropenia caused by neutrophil retention in bone marrow and in WHIM syndrome is associated with lymphopenia and monocytopenia. The CXCR4 antagonist plerixafor mobilizes leukocytes to the blood; however, its safety and efficacy in WHIM syndrome are undefined.

View Article and Find Full Text PDF

Chronic pain conditions like genito-pelvic pain penetration disorder and chronic pelvic pain cause significant morbidity in women worldwide and yet are underdiagnosed and undertreated. While the use of botulinum toxin for pain conditions has expanded, there are few randomized controlled studies of botulinum toxin for pelvic pain conditions in women. This paper provides an update on the current status and context for considering botulinum toxin treatment for these conditions to complement and expand currently available approaches.

View Article and Find Full Text PDF

Endometriosis is a heterogeneous disease where neurogenic sensitization can lead to chronic pain within and beyond the pelvis. Coincident pain and comorbidities merit specific attention. We discuss the causes, comorbidities, and management of endometriosis-associated chronic pelvic pain, advocating for a multidisciplinary approach to develop more effective treatments.

View Article and Find Full Text PDF

Traditionally, there has been a reluctance to involve pregnant people in clinical trials due to complex ethical issues surrounding the risk to unborn babies. However it is crucial that new interventions are safe and effective for all patients and ensuring this can be difficult to achieve in the absence of clinical trials.

View Article and Find Full Text PDF

The health of women remains understudied. In response to a request from Congress, the Office of Research on Women's Health of the National Institutes of Health (NIH) evaluated research on the health of women currently underway related to 1) rising rates of maternal morbidity and mortality, 2) rising rates of chronic debilitating conditions in women, and 3) stagnant cervical cancer survival rates. Input on the three priority areas was obtained from experts in women's health, members of the public, and federal stakeholders.

View Article and Find Full Text PDF

Candida albicans causes debilitating, often azole-resistant, infections in patients with chronic mucocutaneous candidiasis (CMC). Amphotericin B (AMB) resistance is rare, but AMB use is limited by parenteral administration and nephrotoxicity. In this study, we evaluated cochleated AMB (CAMB), a new oral AMB formulation, in mouse models of oropharyngeal candidiasis (OPC) and vulvovaginal candidiasis (VVC) and in patients with azole-resistant CMC.

View Article and Find Full Text PDF

Reproductive health may be adversely impacted in women with dyskeratosis congenita (DC) and related telomere biology disorders (TBD). We evaluated gynaecological problems, fertility, and pregnancy outcomes in 39 females aged 10-81 years who were followed longitudinally in our DC/TBD cohort. Twenty-six had bone marrow failure and 12 underwent haematopoietic cell transplantation.

View Article and Find Full Text PDF
Article Synopsis
  • GATA2 deficiency is treated effectively with hematopoietic cell transplantation (HCT), which helps manage both the deficiency and infection risks, especially from mycobacteria.* -
  • Many patients undergoing HCT for GATA2 deficiency also have persistent human papilloma virus disease (HPVD), which can lead to cancer, and of the 75 patients studied, 49% had anogenital HPVD.* -
  • The study found that while HCT can lead to the resolution of HPVD in some patients, careful and ongoing monitoring post-transplant is essential due to the risk of persistent HPVD and potential complications like cancer.*
View Article and Find Full Text PDF

NO abstract intended, Introduction is listed here The COVID-19 pandemic and call for social justice is occurring when the United States, unlike its peer countries, has already experienced a steady 20-year rise in maternal morbidity and mortality with pregnant women today facing a 50 percent higher risk of mortality than their mothers. 1 Most vulnerable are women of color, black and American Indian/Alaska Native women, who have experienced longstanding disparities in access to and quality of healthcare and may begin pregnancy with hypertension, diabetes, and obesity, complications known to be more common in women enduring segregation. 2-4 Initially, the race-related health disparities and resultant disproportionately higher rates of COVID-19 cases and mortality in indigenous communities and black, latinx, or other communities of color were mistakenly considered innate racial differences.

View Article and Find Full Text PDF

Some chronic pain conditions and comorbidities suppress the hypothalamic-pituitary-adrenal (HPA) axis and response to dynamic testing. We measured HPA axis responses to corticotropin-releasing hormone (CRH) administration in relation to chronic pelvic pain and endometriosis. In a cross-sectional study of women (n = 54) with endometriosis-associated chronic pelvic pain (n = 22), chronic pelvic pain alone (n = 12), or healthy volunteers (n = 20), adrenocorticotropic-releasing hormone (ACTH) and cortisol levels were measured at 0, 15, 30, and 45 min after intravenous ovine CRH administration.

View Article and Find Full Text PDF

Importance: Human papillomavirus (HPV) infection is found in about 40% of women who survive allogeneic hematopoietic stem cell transplant and can induce subsequent neoplasms.

Objective: To determine the safety and immunogenicity of the quadrivalent HPV vaccine (HPV-6, -11, -16, and -18) in clinically stable women post-allogeneic transplant compared with female healthy volunteers.

Interventions: Participants received the quadrivalent HPV vaccine in intramuscular injections on days 1 and 2 and then 6 months later.

View Article and Find Full Text PDF