Publications by authors named "Pamela Salerno"
Consumption of a palatable diet rich in simple sugars during development impairs memory of different degrees of emotionality and changes hippocampal plasticity according to the age of the rats.
Int J Dev Neurosci
August 2020
We investigated the effect of a chronic palatable diet rich in simple sugars on memory of different degrees of emotionality in male adult rats, and on hippocampal plasticity markers in different stages of development. On postnatal day (PND) 21, 45 male Wistar rats were divided in two groups, according to their diet: (1-Control) receiving standard lab chow or (2-Palatable Diet) receiving both standard chow plus palatable diet ad libitum. At PND 60, behavioral tests were performed to investigate memory in distinct tasks.
View Article and Find Full Text PDFThe role of CACNA1C gene and childhood trauma interaction on bipolar disorder.
Prog Neuropsychopharmacol Biol Psychiatry
July 2020
Article Synopsis
- The study investigated how childhood trauma interacts with specific genetic variations in the CACNA1C gene to affect susceptibility to bipolar disorder (BD) in young adults.
- Researchers found no direct link between the gene polymorphisms (rs1006737 and rs4765913) and BD diagnosis, but did observe that childhood trauma significantly impacted the influence of the rs4765913 polymorphism and the AA haplotype on BD susceptibility.
- Specifically, individuals carrying at least one A allele of the rs4765913 polymorphism or the AA haplotype who experienced childhood trauma were more likely to develop BD, highlighting the importance of both genetic and environmental factors in the risk of this complex disease.
Leptin polymorphism rs3828942: risk for anxiety disorders?
Eur Arch Psychiatry Clin Neurosci
September 2021
Article Synopsis
- Leptin is a hormone involved in regulating energy balance and has been linked to psychiatric issues, showing potential antidepressant and anti-anxiety effects.
- A study with 1,067 young adults explored the connection between leptin levels, the LEP gene polymorphism (rs3828942), and anxiety disorders, considering sex differences.
- Findings revealed that while overall leptin levels and the rs3828942 genotype were not linked to anxiety disorders, the A-allele of the polymorphism was associated with a higher risk for generalized anxiety disorder (GAD) in women, indicating sex-dependent effects of leptin on anxiety.
Context: Prostate-specific membrane antigen (PSMA) is expressed in endothelium of vessels in malignant solid tumors but not in normal vessels.
Objective: To examine whether neovasculature of glioblastoma multiforme (GBM) expresses PSMA. Design.