Publications by authors named "Pamela Popken-Harris"
Article Synopsis
- MMTV infection leads to a high rate (90-95%) of mammary tumors in genetically susceptible mice by causing mutations through insertion into their DNA, influenced by steroid hormones.
- Researchers conducted expression profiling to identify the active proto-oncogenes associated with MMTV insertions in tumors, using real-time quantitative RT-PCR to validate results.
- The study suggests that specific MMTV insertions trigger a series of biological changes, establishing a distinct molecular signature characteristic of the tumors induced by these viruses.
