Publications by authors named "Pamela Patricia Tueguem"
HIV drug resistance following pre-exposure prophylaxis failure among key populations in sub-Saharan Africa: a systematic review and meta-analysis protocol.
Ezechiel Ngoufack Jagni Semengue Evariste Molimbou Naomi-Karell Etame Christelle Aude Ka'e Collins Chenwi Ambe Pamela Patricia Tueguem
Ther Adv Infect Dis
December 2024
Article Synopsis
- Key populations (KP), which are crucial in addressing HIV, represent 70% of new infections globally and are the focus of a study examining drug resistance related to PrEP failure in sub-Saharan Africa.
- The research will systematically review various studies to determine the prevalence of HIV drug resistance (HIVDR) among these populations after PrEP failure, analyzing data from diverse groups including gay men, sex workers, and people who inject drugs.
- Findings aim to identify the rates of PrEP failure and drug resistance, helping improve HIV prevention strategies and inform medical practices for effective antiretroviral use in KP within sub-Saharan Africa.
XBB.1, BQ1.1 and atypical BA.4.6/XBB.1 recombinants predominate current SARS-CoV-2 Wavelets with flu-like symptoms in Cameroon: A snapshot from genomic surveillance.
Joseph Fokam Ezechiel Ngoufack Jagni Semengue Davy-Hyacinthe Gouissi Anguechia Naomi-Karell Etame Désiré Takou Pamela Patricia Tueguem
PLOS Glob Public Health
May 2024
As of December 2022, Cameroon had observed a slight resurgence of COVID-19, raising concerns on genomic surveillance of related-SARS-CoV-2 variants under circulation. Following a laboratory-based survey, positive SARS-CoV-2 samples detected from December-2022 through March-2023 were processed for targeted sequencing at the Chantal BIYA International Reference Centre (CIRCB) in Yaoundé-Cameroon. From all positive cases detected, 13 were successfully sequenced (mean age 34 years, 70% female); the majority of the cases were unvaccinated (70%, 9/13) and symptomatic (92%, 12/13); all with flu-like symptoms (100%, 12/12).
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- - WHO suggests COVID-19 antigen rapid tests should have at least 80% sensitivity and 97% specificity, and this study evaluates the INDICAID™ Ag-RDT against RT-PCR as the gold standard, focusing on Omicron variants.
- - The study involved 565 nasopharyngeal swabs, revealing that for samples with higher viral loads (CT < 25), INDICAID™ displayed 100% sensitivity, while still maintaining high specificity and good predictive values.
- - The findings indicate that INDICAID™ Ag-RDT is highly effective for diagnosing COVID-19 in individuals with high viral loads, making it a practical tool for community-level prevention amidst the prevalence of Omicron subvariants.