Publications by authors named "Pamela L. Lutsey"
Background: High-density lipoprotein (HDL) modulates the blood-brain barrier and cerebrovascular integrity, likely influencing the risk of Alzheimer's disease (AD), neurodegeneration, and cognitive decline.
Objective: This study aims to identify HDL protein cargo associated with brain amyloid deposition and brain volume in regions vulnerable to AD pathology in older adults.
Methods: HDL was separated from the plasma of 65 non-demented participants of the Atherosclerosis Risk in Communities (ARIC) study using a fast protein liquid chromatography method.
Introduction: Varicose veins are common in older adults and are associated with adverse clinical outcomes such as deep venous thrombosis. Established risk factors for varicose veins include female sex, height, and obesity, but other risk factors are relatively uncharacterized.
Methods: This was a prospective cohort analysis of 6241 participants aged 66-70 years from the Atherosclerosis Risk in Communities (ARIC) Study.
Air pollution exposure may induce procoagulant effects, and chronic exposure may be linked to greater risk of venous thromboembolism (VTE). We tested the hypothesis that air pollution is associated with increased VTE risk in the prospective Multi-Ethnic Study of Atherosclerosis (MESA), which has well-characterized air pollution measures and information on potential confounding factors. We included 6,651 participants recruited in 2000-2002 (baseline age range: 45-84 yrs; 53% female).
View Article and Find Full Text PDFBackground: Orthostatic hypertension is an emerging risk factor for adverse events. Recent consensus statements combine an increase in blood pressure upon standing with standing hypertension, but whether these 2 components have similar risk associations with cardiovascular disease (CVD) is unknown.
Methods: The ARIC study (Atherosclerosis Risk in Communities) measured supine and standing blood pressure during visit 1 (1987-1989).
Trauma is an established risk factor for venous thromboembolism (VTE). Whether minor trauma is linked to greater risk of VTE remains unclear given that many studies evaluating trauma and VTE risk have not differentiated risk by trauma severity. Furthermore, the underlying risk of VTE is not uniform across all injured patients.
View Article and Find Full Text PDFBackground And Purpose: Lower left atrial (LA) function is associated with higher dementia risk and may be mechanistically linked through vascular brain injury, an established correlate for higher dementia risk. Using data from the Atherosclerosis Risk in Communities study, we assessed the cross-sectional association between LA function and brain magnetic resonance imaging (MRI) markers of vascular brain injury.
Methods: We included 1488 participants who were free of prevalent dementia, stroke, or atrial fibrillation and who underwent a two-dimensional echocardiogram and brain MRI in 2011-2013 (mean [± standard deviation] age 76 [± 5] years, 60% female, 27% Black).
Aims/hypothesis: Prediabetes (HbA 39-47 mmol/mol [5.7-6.4%] or fasting glucose 5.
View Article and Find Full Text PDFCerebral small vessel disease (SVD), as defined by neuroimaging characteristics such as white matter hyperintensities (WMHs), cerebral microhemorrhages (CMHs), and lacunar infarcts, is highly prevalent and has been associated with dementia risk and other clinical sequelae. Although conditions such as hypertension are known to contribute to SVD, little is known about the diverse set of subclinical biological processes and molecular mediators that may also influence the development and progression of SVD. To better understand the mechanisms underlying SVD and to identify novel SVD biomarkers, we used a large-scale proteomic platform to relate 4,877 plasma proteins to MRI-defined SVD characteristics within 1,508 participants of the Atherosclerosis Risk in Communities (ARIC) Study cohort.
View Article and Find Full Text PDFBackground: Biological age may be estimated by proteomic aging clocks (PACs). Previous published PACs were constructed either in smaller studies or mainly in white individuals, and they used proteomic measures from only one-time point. In this study, we created de novo PACs and compared their performance to published PACs at 2 different time points in the Atherosclerosis Risk in Communities (ARIC) study of white and black participants (around 75% white and 25% black).
View Article and Find Full Text PDFImportance: The prevalence of absolute and functional iron deficiency among adults in the US is unknown.
Objective: To estimate the prevalence of absolute and iron deficiency and iron supplement use in the US across age, sex, and comorbidity categories.
Design, Setting, And Participants: This cross-sectional study analyzed data from the National Health and Nutritional Examination Survey (NHANES) 2017 to 2020 prepandemic cycle.
Background: Frailty is common in people with cardiovascular disease. Worse left atrial (LA) function is an independent risk factor for cardiovascular disease. However, whether worse LA function is associated with frailty is unclear.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how mid-life social relationships influence the link between cerebral small vessel disease (CSVD) markers seen in MRI scans and the risk of developing dementia in older adults.
- Researchers evaluated participants from the ARIC Study, examining their social support and isolation, and then later assessed CSVD measures and dementia cases over time.
- Results indicated that poor social relationships intensified the association between white matter hyperintensity volume and dementia risk, with a notably higher hazard ratio for those with weak social ties compared to those with strong relationships.
Direct oral anticoagulants (DOACs; rivaroxaban, apixaban) and warfarin are approved for venous thromboembolism (VTE) treatment. Few direct comparisons of DOACs on risk of mortality among VTE patients exist, and for patients with concomitant conditions (e.g.
View Article and Find Full Text PDFArticle Synopsis
- * It analyzes data from the Atherosclerosis Risk in Communities Study, including diverse participants from four US communities, with an average follow-up period of nearly 19 years.
- * Findings suggest that individuals who lived in lower SES neighborhoods during middle adulthood had a significantly higher risk of dying before age 75 compared to those from higher SES neighborhoods.
Background: Numerous studies have shown inverse associations between serum magnesium (Mg) and risk of cardiovascular disease (CVD), but studies of dietary Mg have not been consistent.
Aim: To examine the association of a Mg-rich diet score with risks of CVD, coronary heart disease (CHD), and ischemic stroke in the Atherosclerosis Risk in Communities (ARIC) study.
Methods: There were 15,022 Black and White adults without prevalent CVD at baseline (1987-89) included in this analysis.
Background: We sought to evaluate the associations of chest pain and dyspnea with the long-term risk of cardiovascular disease including coronary disease, heart failure, atrial fibrillation, and stroke.
Methods: In 13,200 participants without cardiovascular disease in the Atherosclerosis Risk in Communities study (1987-1989), chest pain was categorized into definite angina, possible angina, non-anginal chest pain, and no chest pain using the Rose questionnaire. Dyspnea was categorized into grades 3-4, 2, 1, and 0 by the modified Medical Research Council scale.
Aims: Few studies investigate whether psychosocial factors (social isolation, social support, trait anger, and depressive symptoms) are associated with cardiovascular health, and none with the American Heart Association's new definition of cardiovascular health, Life's Essential 8 (LE8). Therefore, we assessed the cross-sectional associations of psychosocial factors with Life's Essential 8 and individual components of Life's Essential 8.
Methods: We included 11,311 Atherosclerosis Risk in Communities cohort participants (58% females; 23% Black; mean age 57 (standard deviation: 6) years) who attended Visit 2 (1990-1992) in this secondary data analysis using cross-sectional data from the ARIC cohort study.
Article Synopsis
- Plasma biomarkers may help identify Alzheimer’s disease and the need for further research across diverse populations and age groups.
- The study involved 1,525 participants from the Atherosclerosis Risk in Communities (ARIC) study, measuring biomarkers in midlife and late life to assess changes and associations with dementia.
- Results showed a decline in the Aβ42:Aβ40 ratio and increases in p-tau181, neurofilament light (NfL), and GFAP, indicating a link between these changes and the development of dementia in the participants.
Article Synopsis
- Anemia is linked to higher all-cause mortality in older adults, with participants having anemia showing significantly increased risks for death due to cardiovascular disease, cancer, and respiratory disease.
- Over a median follow-up of 7.5 years, 21% of participants were found to have anemia, leading to 1,147 deaths in total.
- However, low ferritin levels in non-anemic individuals didn't show a strong connection to mortality, except for cancer mortality in men with low inflammation.
Article Synopsis
- Cigarette smoking is known to alter DNA methylation at the AHRR gene, but this study investigates whether non-cigarette tobacco use, like pipe and cigar smoking, also affects AHRR methylation and health outcomes.
- Data from four cohorts (1985-2002) revealed that exclusive non-cigarette tobacco users had lower AHRR methylation compared to those who smoked cigarettes, with non-cigarette users showing less dramatic effects.
- The results indicate that lower AHRR methylation in non-cigarette tobacco users is linked to worse respiratory symptoms and higher mortality rates, suggesting AHRR methylation could be a marker for health risks among these smokers.
Association of Left Atrial Function With Incident Chronic Kidney Disease in Older Adults.
Mayo Clin Proc Innov Qual Outcomes
August 2024
Article Synopsis
- The study aimed to explore the link between left atrial (LA) function and the development of chronic kidney disease (CKD), and to determine if including LA function could improve CKD risk prediction models.
- In a group of 4,002 participants (average age 75), researchers found that lower LA function was associated with a higher risk of developing CKD over a median follow-up of 7.2 years, with 598 cases emerging during this period.
- Incorporating LA function data into existing CKD prediction models improved risk assessment accuracy and demonstrated greater clinical utility, indicating that impaired LA function might serve as a new risk factor for CKD.
Objective: The impact of age of diabetes diagnosis on dementia risk across the life course is poorly characterized. We estimated the lifetime risk of dementia by age of diabetes diagnosis.
Research Design And Methods: We included 13,087 participants from the Atherosclerosis Risk in Communities Study who were free from dementia at age 60 years.
Stroke is a leading cause of death in the United States across all race/ethnicity and sex groups, though disparities exist. We investigated the potential for primary prevention of total first stroke for Americans aged 20 years or older, stratified by sex and race/ethnicity. Specifically, we calculated population attributable fractions (PAFs) of first stroke for 7 potentially modifiable risk factors: smoking, physical inactivity, poor diet, obesity, hypertension, diabetes, and atrial fibrillation.
View Article and Find Full Text PDFBackground: Brain imaging studies may provide etiologic insight into observed links between lung function and dementia and stroke.
Objective: We evaluated associations of lung function measures with brain MRI markers of vascular and neurodegenerative disease in the ARIC Neurocognitive Study, as few studies have examined the associations.
Methods: Lung function was measured at participants' midlife in 1990-1992 (mean age = 56±5 years) and later-life in 2011-2013 (mean age = 76±5 years), and brain MRI was performed in 2011-2013.
Background: Multiple myeloma (MM) is associated with high risk of venous thromboembolism (VTE). Anticoagulant prophylaxis is frequently recommended but underutilized partly due to the absence of studies assessing bleeding risk.
Objectives: To determine the rate of severe (hospitalized) bleeding from thromboprophylaxis in patients treated for MM and identify clinical risk factors for bleeding in this population.