Synopsis of recent research by authors named "Pamela L Russ"
Recent research by Pamela L Russ focuses on the synthesis and analysis of nucleoside analogues, particularly their effects on enzyme inhibition and antiviral activity.
One notable study explores locked carbocyclic analogues of 1,3-diazepinone riboside, revealing that structural modifications significantly impact the inhibition of cytidine deaminase, a key enzyme in nucleoside metabolism.
Another study investigates North- and South-bicyclo[3.1.0]hexene nucleosides, demonstrating how ring planarity affects their anti-HIV properties, highlighting the importance of structural conformation in drug design.
