Family resemblance for Preece-Baines growth curve parameters in the fels longitudinal growth study.

The Preece-Baines Model 1 (PB1) nonlinear regression equation was fit to serial stature measurements from 456 participants in the Fels Longitudinal Growth Study. The resulting model parameters and derived biological parameters, such as age, stature, and velocity at take-off (TO) and peak velocity (PV) are analyzed for family resemblance in 228 nuclear families through estimation of familial correlations and path coefficients. Significant family resemblance was found for all of the growth parameters.

Model fitting to early childhood length and weight data from the fels longitudinal study of growth.

Length and weight data from 3 months to 6 years of age from 466 participants in the Fels Longitudinal Study of Growth were used to fit the Jenss non-linear growth curve. Six (1%) of the Fels participants had extremely outlying values for length parameters, and 20 (4%) had outlying values for weight parameters. The general pattern in the outliers is for average or below average size in infancy, followed by unusually rapid growth or weight gain in childhood.

Family resemblance for patterns of growth in early childhood.

Parameters of the Jenss curve representing linear and non-linear components of growth in early childhood were fitted to longitudinal recumbent length and weight measurements from participants in the Fels Longitudinal Growth Study. Nuclear family correlations were estimated for each of four Jenss parameters (a linear intercept and slope and a non-linear intercept and degree of curve) for length and for weight. The TAU path model was fit to the correlations, in order to estimate path coefficients representing transmissibility from parent to child (t ) and non-transmissible sibling resemblance (s).

Relationship between clinical parameters and linear growth in children with cystic fibrosis.

Mixed longitudinal height data from 1,170 cystic fibrosis patients seen at Rainbow Babies and Childrens Hospital in Cleveland form the basis for this analysis. As a group, the patients experience growth retardation throughout the growth cycle, with median height values below the 25th percentile of NCHS standards until late adolescence. Median height increments are also below normal standards until age 16 years in boys and 14 years in girls.

X-linked pattern of inheritance for serial measures of weight/stature.

The pattern of family resemblance for long-term serial measures of weight/stature (W/S ) in approximately 500 individuals from the Fels Longitudinal Growth Study suggests that X-linked genes may be contributing to the variability in this trait among children, particularly during the prepubertal age range of 2-9 years. In this data set, W/S was measured serially at the same ages in all family members. Thus, a parent-child correlation at a specific age can be determined even though the measurements were made on the child a generation later than on the parent.