A real-world study assessing the use of bone-targeted agents and their impact on bone metastases in patients with prostate cancer treated in clinical practice in Europe.

Background: Bone metastases (BMs) are common in patients with prostate cancer and can lead to skeletal-related events (SREs), which are associated with increased pain and reduced quality of life (QoL). Bone-targeted agents (BTAs), such as zoledronic acid and denosumab, reduce the incidence of SREs and delay progression of bone pain.

Methods: We evaluated the management of BMs and pain in six European countries (Belgium, France, Germany, Italy, Spain and the UK) using the Adelphi Prostate Cancer Disease Specific Programme.

Real-world treatment patterns and outcomes of patients with stage IV squamous cell carcinoma of the head and neck.

Aim: To understand the treatment patterns and outcomes for stage IV squamous cell carcinoma of the head and neck, patients receiving second-line or later drug therapy.

Materials & Methods: Real-world data were collected from 1152 patients in the USA, France, Germany and the UK through a retrospective chart analysis and patient-reported outcomes were collected using validated questionnaires in a subgroup of patients.

Results: Forty-four percent of patients had stage IVA/B disease.

Interference between auditory and visual duration judgements suggests a common code for time.

Auditory stimuli usually have longer subjective durations than visual ones for the same real duration, although performance on many timing tasks is similar in form with different modalities. One suggestion is that auditory and visual stimuli are initially timed by different mechanisms, but later converted into some common duration code which is amodal. The present study investigated this using a temporal generalization interference paradigm.