Publications by authors named "Pamela Dilworth"
Objectives: To examine whether incidence of colorectal malignancy is increased in Australasian liver transplant recipients compared with the general population of Australia, and to assess the characteristics and outcomes of colorectal malignancy in this patient group.
Design, Setting And Patients: Data on patients who underwent orthotopic liver transplantation (OLTx) and had a diagnosis of de-novo colorectal malignancy after transplantation during the period 1985-2011 were obtained from the Australia and New Zealand Liver Transplant Registry, and these data were compared with colorectal malignancy data from the Australian Institute of Health and Welfare.
Main Outcome Measures: Time from OLTx to diagnosis of colorectal malignancy, stage of colorectal malignancy at diagnosis, patient survival, and standardised incidence ratio (SIR) for colorectal malignancy.
Article Synopsis
- Donor liver steatosis significantly affects liver transplant outcomes, with microvesicular (MiS) and macrovesicular steatosis (MaS) identified in a large percentage of biopsies.
- Certain donor factors, like increased body mass index and male sex, are linked to allograft steatosis, while severe MaS correlates with serious complications such as primary non-function and the need for retransplantation.
- The study concludes that only moderate to severe MaS negatively impacts early allograft survival, showing a stronger effect than other donor risk indicators like the Donor Risk Index (DRI).
Although 1-year survival rates following liver transplantation over the last 20 years may have improved, there is doubt about improvement in long-term survival. We examined survival with and without initial 12-month mortality in adult liver transplant recipients over a 20-year period. Patient and allograft survival for 3 different time periods was compared: 1986-1994 (group 1, n = 547), 1995-2000 (group 2, n = 735), and 2000-2005 (group 3, n = 749).
View Article and Find Full Text PDFBackground: Vascular conduits may be required to gain arterial inflow to the donor hepatic artery in orthotopic liver transplantation.
Methods: From January 1986 to December 2003, arterial conduits were required in 31/582 (5.3%) adult liver transplant procedures.