Publications by authors named "Pamela Casanova-Trivino"
Diagnostic Performance of Tc-iPSMA SPECT/CT in the Initial Staging of Patients with Unfavorable Intermediate-, High-, and Very High-Risk Prostate Cancer: A Comparative Analysis with F-PSMA-1007 PET/CT.
Joel E Vargas-Ahumada Sofía Denisse González-Rueda Fabio Andrés Sinisterra-Solís Pamela Casanova-Triviño Quetzali Pitalúa-Cortés
Cancers (Basel)
December 2023
Article Synopsis
- Prostate cancer is a major health issue for men globally, and advanced imaging techniques, particularly PSMA imaging with PET/CT, are crucial for its detection and staging.
- This study compares the diagnostic accuracy of two imaging methods, Tc-EDDA/HYNIC-iPSMA SPECT/CT and F-PSMA-1007 PET/CT, in patients with confirmed prostate cancer, involving 18 participants with high-risk disease characteristics.
- Results indicated that while F-PSMA-PET/CT detected more lesions overall, Tc-iPSMA SPECT/CT was still effective for primary diagnosis and did not significantly alter clinical staging or treatment plans.
Fibroblast activation protein (FAP) is highly expressed on the cancer-associated fibroblasts (CAF) of the tumor stroma. Recently, we reported the preclinical evaluation and clinical biokinetics of a novel Tc-labeled FAP inhibitor radioligand ([Tc]Tc-iFAP). This research aimed to evaluate [Tc]Tc-iFAP for the tumor stroma imaging of six different cancerous entities and analyze them from the perspective of stromal heterogeneity.
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