The effect of diagnostic confidence on the probability of optical colonoscopic confirmation of potential polyps detected on CT colonography: prospective assessment in 1,339 asymptomatic adults.

Objective: We sought to evaluate the effect of interpreter confidence on the likelihood that a lesion detected on CT colonography (CTC) will correspond to a matched polyp seen on optical colonoscopy.

Subjects And Methods: Same-day CTC and optical colonoscopy were performed on 1,339 asymptomatic adults. A standard matching algorithm for polyp size and location was used.

Flat colorectal lesions in asymptomatic adults: implications for screening with CT virtual colonoscopy.

Objective: The clinical significance of flat lesions in colorectal cancer screening remains uncertain. The purpose of this study was to investigate the frequency, histology, and virtual colonoscopy detection of flat lesions in an asymptomatic screening population.

Subjects And Methods: The morphology of all detected polyps was prospectively recorded as flat or polypoid (sessile or pedunculated) in 1,233 consecutive asymptomatic adults who underwent same-day virtual colonoscopy and optical colonoscopy.

Location of adenomas missed by optical colonoscopy.

Background: Previous estimates of the adenoma miss rate with optical colonoscopy (OC) are hindered by the use of OC as its own reference standard.

Objective: To evaluate the frequency and characteristics of colorectal neoplasms that are missed prospectively on OC by using virtual colonoscopy (VC) as a separate reference standard.

Design: Prospective, multicenter screening trial.

Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults.

Background: We evaluated the performance characteristics of computed tomographic (CT) virtual colonoscopy for the detection of colorectal neoplasia in an average-risk screening population.

Methods: A total of 1233 asymptomatic adults (mean age, 57.8 years) underwent same-day virtual and optical colonoscopy.