Different activation of mitogen-activated protein kinase and Akt signaling is associated with aggressive phenotype of human meningiomas.

Purpose: Activation of intracellular signaling cascades has been implicated in the growth control of benign meningiomas, but their role for meningioma progression and outcome is unknown. Here we determined the expression and function of proteins involved in mitogen-activated protein kinase (MAPK) and phosphinositol-3 kinase (PI3K)/Akt signaling in benign, atypical, and malignant meningiomas and studied their association with clinicopathologic data including meningioma recurrence.

Experimental Design: Expression of various MAPK and PI3K signaling proteins was determined in 70 primary meningiomas and, if present, in recurrent tumors by immunohistochemistry and Western blotting.

[Induratio penis plastica].

Background: To evaluate the benefit of radiotherapy with fast electrons in induratio penis plastica (IPP).

Patients And Methods: Within 7 years we treated 58 patients with manifested clinically induratio penis plastica. We applied single dose of 3 Gy 2-3 times weekly and a maximum dose of 24-30 Gy.