[Heterocyclic systems. III. Synthesis and CNS activity of derivatives of pyrrole(2,1-c) (1,4)benzodiazocine].

5,11-Dioxo-1,2,3,5,6,11,12,12a-octahydropyrrolo [2,1-c] [1,4]benzodiazepine and the corresponding 2-hydroxyderivative were prepared by the intramolecular cyclization of 1-(2-aminophenylacetyl)pyrrolidin-2-carboxylic acid and 1-(2-aminophenylacetyl)-4-hydroxypyrrolidin-2-carboxylic acid; some of the tricyclic compounds were tested for neuropsychopharmacological effects.

Direct evidence in men for a role of endogenous oestrogens on gonadotrophin release.

In six healthy subjects serum oestradiol was selectively decreased by administering an aromatase activity inhibitor, hydrotestolactone (HT). After HT administration serum oestradiol (Oe2) decreased from 18.7 +/- 2.

Human fetal insulin secretion in response to maternal glucose and leucine administration.

Maternal and fetal serum insulin response to glucose, leucine and leucine plus glucose was examined by infusions to normal pregnant women at term immediately before cesarean section. The maternal infusion of glucose (50 g) for 30 or 60 minutes was associated with a marked hyperglycemia and with a rise in serum insulin in mother and fetus. The fetal insulin response to the administration of glucose for 60 minutes was higher (p less than 0.

Concerning a new pathogenetic hypothesis of the E.P.H. gestosis (note I).

The Authors, after having evaluated the literature data, report, on the basis of their clinical experience, a new pathogenic hypothesis of the E.P.H.

Concerning a new pathogenetic hypothesis of the E.P.H. gestosis (note II).

In this second note, the Authors report a new therapeutic protocol, based on the aetiopathogenesis, of the E.P.H.

Interaction of apoA-II from human high density lipoprotein with lysolecithin.

The effects of lysolecithin and hexadecyltrimethylammonium bromide on the structure and stability of apoA-II from human high density lipoprotein have been evalued by circular dichroism and fluorescence measurements. There is a profound enhancement in the stability of apoA-II to guanidinium hydrochloride denaturation when it forms a phospholipid complex with lysolecithin micelles. This complex is not only resistant to guanidinium hydrochloride denaturation, but it can be formed in a 6 M solution of this denaturant.

Human maternal and fetal serum insulin and growth hormone (HGH) response to glucose and leucine.

Maternal and fetal serum insulin and HGH responses to glucose, leucine, and glucose plus leucine were examined by infusions to pregnant women at term immediately before cesarean section. Leucine (15 gm.) with glucose (50 gm.

The interaction of apoA-I from human high density lipoprotein with lysolecithin.

The binding of apoA-I to lysolecithin has been studied by fluorescence and circular dichroism. The influence of the conformation of apoA-I on its interaction with lysolecithin has also been evaluated. ApoA-I is bound to lysolecithin with an association greater than 10(7) whether apoA-I is native or highly unfolded in 1.

The self-association of the reduced ApoA-II apoprotein from the human high density lipoprotein complex.

The molecular properties of the single linear chain form of human apoA-II, i.e., Cm apoA-II, have been evaluated by circular dichroism, polarization of fluorescence, difference absorption, and sedimentation equilibrium.

Relative orientation with respect to the centromere of ribosomal RNA genes of the X and Y chromosomes of Drosophila melanogaster.

We tested for recombination within the DNA that codes for ribosomal RNA (rDNA) on the X and Y chromosomes of Drosophila melanogaster. The criterion was the appearance of intermediate bb alleles on X-Y recombinants from wild bb(+) and lethal bb(1) loci carried on parental chromosomes. Recombination within the rDNA occurs only when the rDNA of the X chromosome is inverted.