Deciphering the fluorescence resonance energy transfer signature of 3-pyrazolyl 2-pyrazoline in transport proteinous environment.

In the present investigation, an attempt has been made to study the interaction of newly synthesized bioactive compound 3-pyrazolyl 2-pyrazoline (PZ) with model transport proteins, bovine serum albumin (BSA), and human serum albumin (HSA) employing steady state and time-resolved fluorescence technique. We have focused on fluorescence resonance energy transfer (FRET) between excited tryptophan in transport proteins to transport-proteins-bound PZ. An efficient Forster-type resonance energy transfer from the tryptophan residues to PZ indicates that PZ binds in the vicinity of the tryptophan residue.

Sorption of water vapor, hydration, and viscosity of carboxymethylhydroxypropyl guar, diutan, and xanthan gums, and their molecular association with and without salts (NaCl, CaCl2, HCOOK, CH3COONa, (NH4)2SO4 and MgSO4) in aqueous solution.

Gums are routinely used in food industry, pharmacy and oil recovery process. In these uses, the hydrocolloids very often encounter interactions with salts at moderate to high temperature. Since they are normally employed in the form of solution and gel, their viscous or fluidity properties need detailed investigation.

Role of hydrogen bonding on the spectroscopic properties of thiazolidinedione derivatives in homogeneous solvents.

In this work, three newly synthesized derivatives of thiazolidinediones, with potential for application as drugs in pharmaceutical industry and free radical scavenging activity, have been taken up to investigate their behaviour in different homogeneous solvents. The purpose of this work is to study the solvation characteristics in ground and excited states of the derivatives by monitoring the absorbance and fluorescence band maxima. The steady state and time resolved fluorescence studies in protic and aprotic solvents have been rationalized on the basis of solute-solvent interaction and substituent effect on these photophysical processes have been analyzed.

Substituent effect on the emission behavior of thiazolidinedione derivatives in cationic and anionic micellar media.

Thiazolidinedione (TZD) derivatives have been found to possess potent immunostimulatory properties as well as antiarthritic, antidiabetic and oncostatic activities. These compounds are free radical scavengers. Photophysical properties of the compounds have been studied in different aqueous micellar environments using steady state and time resolved emission spectroscopy.

Spectroscopic investigation of 3-pyrazolyl 2-pyrazoline derivative in homogeneous solvents.

How solvent conditions such as solvent polarity and hydrogen-bonding affect the fluorescence of a newly synthesized 3-pyrazolyl 2-pyrazoline derivative (Pyz) having pharmaceutical activity has been explored. The solvatochromic effect of Pyz is due to a change in dipole moment of the compound in the excited state. The relaxation of S1 state is perturbed in hydrogen-bonding solvents.

Modulated photophysics of 3-pyrazolyl-2-pyrazoline derivative entrapped in micellar assembly.

The photophysical behavior of 3-pyrazolyl-2-pyrazoline derivative (PZ), a newly synthesized biologically active compound has been studied in micellar solutions of anionic sodium dodecyl sulfate (SDS), cationic cetyl trimethylammonium bromide (CTAB) and nonionic p- tert-octylphenoxy polyoxyethanol (Triton X-100, TX-100) micelle using steady state and time-resolved fluorescence spectroscopy technique. Influence of the micelles on the photophysics of PZ has also been investigated using different approaches. The location of the fluorophore PZ in the micelle has been identified by cetyl pyridinium chloride (CpCl) induced fluorescence quenching and micropolarity surrounding that fluorophore in micellar solution.

Spectroscopic studies of 2-(2-bromo-ethyl)-6-nitro-benzo[de]isoquinolene-1,3-dione in water/alkanol mixed solvents and nonionic micelle of Igepal CO series.

Spectroscopic studies of newly synthesized bioactive compound 2-(2-bromo-ethyl)-6-nitro-benzo[de]isoquinolene-1,3-dione (BNBIO) have been carried out in polar aprotic solvent, viz. acetonitrile, tetrahydrofuran, 1,4-dioxan, ethylene glycol, dimethyl formamide, and polar protic solvent, viz. methanol, ethanol, propanol, water.