Background: Primary care interventions that promote cessation of benzodiazepine (BZD) use in long-term users are effective at 1 year, but their efficacy at 3 years is uncertain.
Aim: To assess the 3-year efficacy of two primary care interventions delivered by GPs on cessation of BZD use in long-term users.
Design And Setting: Multicentre, three-arm, cluster randomised, controlled trial, with random allocation at the GP level.
Background: Emotional disorders (depression and anxiety disorders) are highly prevalent mental health problems. Although evidence showing the effectiveness of disorder-specific treatments exists, high comorbidity rates among emotional disorders limit the utility of these protocols. This has led some researchers to focus their interest on transdiagnostic interventions, a treatment perspective that might be more widely effective across these disorders.
View Article and Find Full Text PDFBackground: Benzodiazepines are extensively used in primary care, but their long-term use is associated with adverse health outcomes and dependence.
Aims: To analyse the efficacy of two structured interventions in primary care to enable patients to discontinue long-term benzodiazepine use.
Method: A multicentre three-arm cluster randomised controlled trial was conducted, with randomisation at general practitioner level (trial registration ISRCTN13024375).
Background: Although benzodiazepines are effective, long-term use is not recommended because of potential adverse effects; the risks of tolerance and dependence; and an increased risk of hip fractures, motor vehicle accidents, and memory impairment. The estimated prevalence of long-term benzodiazepine use in the general population is about 2,2 to 2,6%, is higher in women and increases steadily with age. Interventions performed by General Practitioners may help patients to discontinue long-term benzodiazepine use.
View Article and Find Full Text PDFObjective: To analyze whether for an equal health problem there are gender differences in the drugs used in an adult population attended in the Health Care Centers of the Valencian Community (Spain).
Methods: A cross-sectional analytical study was carried out between February-August 1997. The independent variables were: socio-economic parameters, frequency of visits, and self-perceived or diagnosed health problems, and the dependent one the number of drugs consumed.
Objective: To assess the quality and relevance of adverse drug reactions (ADRs) published as Letters to the Editor (LE) in Spanish medical journals.
Design: Observational study.
Participants: LE on adverse drug reactions published over 5 years (1994-98).
Background: Indication-based, in comparison to diagnoses-based, drug utilization studies in children are scarce in the literature.
Aim: To determine the adequacy of the prescriber's indications for specific drug treatments compared to the current literature in five different European countries; and to show the possibilities of performing indication-based drug utilization studies.
Design: a descriptive, cross-sectional, international study.
Introduction: Scarce information about comparative diagnostic and therapeutic patterns in paediatric outpatients of different countries is found in the literature.
Objective: To describe the similarities and differences observed in diagnosis and therapeutic patterns of paediatric patients of seven locations in different countries.
Design: Cross-sectional, prospective, international comparative, descriptive study.
Objective: To describe patterns observed in the treatment of acute otitis media (AOM) in several locations of five countries.
Patients And Methods: Cross-sectional, descriptive study. Random sample of 12,264 paediatric outpatients seen by paediatricians or general practitioners (GPs).
Objective: To analyze the case reports concerning children (14 years or younger) in the Spanish Pharmacovigilance System over a 10-year period (1982-1991).
Findings: The study of 1419 reports of adverse drug reaction (9.8% of all those received) showed the most commonly involved organs and systems to be the skin, digestive tract, and nervous system (62.
1. A study is made of the contractile and relaxant effects, and mechanism of action, of histamine on isolated uterus from mice treated with diethylstilboestrol, employing acetylcholine and adrenaline as contractile and relaxant standard agents. 2.
View Article and Find Full Text PDFBr J Clin Pharmacol
June 1999
Aims: There are few publications of adverse drug reactions (ADRs) among paediatric patients, though ADR incidence is usually stated to be higher during the first year of life and in male patients. We have carried out a prospective study to assess the extent, pattern and profile risk for ADRs in hospitalized patients between 1 and 24 months of age.
Methods: An intensive events monitoring scheme was used.
1. We carried out experiments in anesthetized rats to study the hemodynamic effects of intravenous injections of epinine. 2.
View Article and Find Full Text PDFObjective: To describe two cases of stomatitis related to fluoxetine given for the treatment of depression that were detected in the hospital emergency department.
Data Synthesis: Two women developed stomatitis after the intake of fluoxetine for the treatment of depression. One of the patients had six recurrent episodes of stomatitis without suspecting an association with fluoxetine.
Br J Clin Pharmacol
September 1996
1. A total of 512 consecutive paediatric hospital admissions of children 2 years old or less were evaluated to assess the extent and pattern of admission caused by suspected adverse drug reactions (ADRs). the proportion of suspected ADRs related to hospital admissions was 4.
View Article and Find Full Text PDFPharmacoepidemiol Drug Saf
July 1996
Unlabelled: In an attempt to assess the relative toxicity of amoxycillin and amoxycillin-clavulanic acid, we compared the adverse drug reactions reports collected using the spontaneous reporting system of a Regional Drug Surveillance Centre of Spain for both drugs between November 1986 and December 1992. During the 7-year period 1986-92, the 247 reports of amoxycillin-clavulanic acid represent twice the number of reports of amoxycillin alone, and the number of reports related with sales received concerning the association were higher than those concerning amoxycillin alone. The adverse effects classified as severe were quantitatively and qualitatively similar for both drugs and gastrointestinal and skin are the most common system-organ affected by both drugs.
View Article and Find Full Text PDF