Fezolinetant and Elinzanetant Therapy for Menopausal Women Experiencing Vasomotor Symptoms: A Systematic Review and Meta-analysis.

Objective: To assess the efficacy and safety of fezolinetant and elinzanetant for vasomotor symptoms in menopausal women.

Data Sources: MEDLINE, EMBASE, and Cochrane databases were systematically searched until August 22, 2024. Because the Cochrane Library included all the identified randomized controlled trials (RCTs), it was unnecessary to search ClinicalTrials.

Reduced expression of in differentiated thyroid cancer, the contribution of CPG methylation, and their clinical relevance.

Introduction: Forkhead box E1 () is a transcription factor with a crucial role in thyroid morphogenesis and differentiation. Promoter hypermethylation downregulates expression in different tumor types; nevertheless, its expression and relationship with methylation status in differentiated thyroid cancer (DTC) remain unclear.

Methods: A total of 33 pairs of matched samples of PTC tumors and non-tumors were included.

Mifepristone and misoprostol versus misoprostol alone for induction of labor in women with intrauterine fetal death: A meta-analysis and systematic review.

Background: Misoprostol is largely used in labor induction in cases of intrauterine fetal death. However, recent randomized clinical trials (RCTs) showed that the combination of mifepristone and misoprostol might have better effects than the use of misoprostol alone.

Objectives: To compare mifepristone and misoprostol lines of treatment.

Transcranial direct current stimulation on hypertension: a systematic review and meta-analysis.

Hypertension is a clinical condition that presents an enormous prevalence worldwide. Despite there being gold-standard treatments, several people frequently present sequelae and die. Transcranial direct current stimulation (tDCS) emerges as a cheap, easy-to-use, and portable intervention to modulate the central nervous system and control cardiovascular parameters.

The transcriptional regulator Fur modulates the expression of uge, a gene essential for the core lipopolysaccharide biosynthesis in Klebsiella pneumoniae.

Background: Klebsiella pneumoniae is a Gram-negative pathogen that has become a threat to public health worldwide due to the emergence of hypervirulent and multidrug-resistant strains. Cell-surface components, such as polysaccharide capsules, fimbriae, and lipopolysaccharides (LPS), are among the major virulence factors for K. pneumoniae.

Emotional intelligence of health personnel and safety climate in hospitals during the COVID-19 pandemic.

Objective: To analyze the relationship between the emotional intelligence of healthcare workers in a hospital environment and their perception of the safety climate in the COVID-19 pandemic.

Method: Cross-sectional, analytical study, carried out with 81 health workers who worked in hospitals during the pandemic, between September and November 2021. Data collection was carried out using an electronic form, which included a sociodemographic/occupational questionnaire and the Brazilian versions of the Safety Attitudes Questionnaire and the Schutte Self Test.

Hypertonic Saline Solution Versus Mannitol for Brain Relaxation During Craniotomies: A Systematic Review and Updated Meta-Analysis.

Background And Objectives: The preferred osmotic agent used for brain relaxation during craniotomies remains unclear, either mannitol (MAN) or hypertonic saline (HTS). Hence, we sought to compare these solutions in this population.

Methods: MEDLINE, Embase, and Cochrane databases were systematically searched until August 02, 2023.

Laser auriculotherapy associated with cupping therapy in chronic spinal pain: Randomized controlled clinical trial.

Background: Musculoskeletal spine disorders are common causes of chronic pain and impair functionality. Laser auriculotherapy and cupping has played a significant role in the treatment of chronic pain.

Objective: to evaluate the effect of laser auriculotherapy associated with cupping at systemic acupuncture points on chronic spinal pain.

Selection and validation of reference genes suitable for gene expression analysis by Reverse Transcription Quantitative real-time PCR in Acinetobacter baumannii.

Acinetobacter baumannii is a Gram-negative bacterium considered an emerging multi-drug-resistant pathogen. Furthermore, this bacterium can survive in extreme environmental conditions, which makes it a frequent cause of nosocomial infection outbreaks. Gene expression analyses by Reverse Transcription Quantitative real-time PCR (RT-qPCR) depend on a reference gene, also called an endogenous gene, which is used to normalize the generated data and thus ensure an accurate analysis with minimal errors.

Lysicamine Reduces Protein Kinase B (AKT) Activation and Promotes Necrosis in Anaplastic Thyroid Cancer.

Anaplastic thyroid cancer (ATC) is an aggressive form of thyroid cancer (TC), accounting for 50% of total TC-related deaths. Although therapeutic approaches against TC have improved in recent years, the survival rate remains low, and severe adverse effects are commonly reported. However, unexplored alternatives based on natural compounds, such as lysicamine, an alkaloid found in plants with established cytotoxicity against breast and liver cancers, offer promise.

Normalization of deviance in pediatric hospital: perception of health workers.

Objective: To know the perception of health workers about the phenomenon of normalization of deviance in a pediatric hospital.

Method: Exploratory, descriptive, and qualitative study conducted in a public pediatric hospital in northeastern Brazil in 2021. An in-depth interview was applied to 21 health workers, submitted to Thematic Categorical Content Analysis in the MAXQDA® Software.

Integrative and complementary practices to control nausea and vomiting in pregnant women: a systematic review.

Objective: to synthesize the evidence available in the literature on the effects of integrative and complementary practices in nausea and vomiting treatment in pregnant women.

Method: a systematic review, reported according to PRISMA and registered in PROSPERO. The search for studies was carried out in 11 databases.

Transcranial Direct Current Stimulation on Parkinson's Disease: Systematic Review and Meta-Analysis.

Clinical impact of transcranial direct current stimulation (tDCS) alone for Parkinson's disease (PD) is still a challenge. Thus, there is a need to synthesize available results, analyze methodologically and statistically, and provide evidence to guide tDCS in PD. Investigate isolated tDCS effect in different brain areas and number of stimulated targets on PD motor symptoms.

Hydrodynamic and Performance Evaluation of a Porous Ceramic Membrane Module Used on the Water-Oil Separation Process: An Investigation by CFD.

Wastewater from the oil industry can be considered a dangerous contaminant for the environment and needs to be treated before disposal or re-use. Currently, membrane separation is one of the most used technologies for the treatment of produced water. Therefore, the present work aims to study the process of separating oily water in a module equipped with a ceramic membrane, based on the Eulerian-Eulerian approach and the Shear-Stress Transport (SST k-ω) turbulence model, using the Ansys Fluent 15.

Increasing thermal stress with flight distance in stingless bees (Melipona subnitida) in the Brazilian tropical dry forest: Implications for constraint on foraging range.

The thoracic temperature (T) of foraging bees usually exceeds ambient air temperatures (T) by several degrees. In hot tropical climate zones, therefore, individuals may reach body temperatures close to their critical thermal maxima, which might constrain their activity. In the present study, we tested the hypothesis that thermal stress increases with flight distance in nectar foragers of M.

Comparative thermographic analysis at pre- and postcryolipolysis treatment: Clinical case report.

Introduction: Although the exact cryolipolysis mechanisms on adipose tissue remain unknown, the current literature indicates that it may occur a crystallization followed by an ischemic reaction which generates an inflammatory process.

Objective: To evaluate thermographically, the tissue's circulatory pattern of a patient submitted to the cryolipolysis technique and the beginning of the inflammatory process, through variations of temperature gradients and the evaluation of the pains degree of the patient in these same moments.

Methods: A descriptive study, of an interventional case report, performed in an 18-year-old patient who had clearly visible fat in the lower abdomen area, with a skin fold greater than 2 centimeters and body mass index ≤ 30 kg/m .

Maintenance of tobacco withdrawal by former smokers: a phenomenological study.

OBJECTIVE To understand the experience of former smokers maintaining tobacco abstinence. METHODS Qualitative research using the theoretical-methodological reference of the Social Phenomenology, as defined by Alfred Schütz. The phenomenological interview was carried out in 2016 with 12 former smokers from a city in the state of Minas Gerais, Brazil.

Effects of long-term low-dose dietary creatine supplementation in older women.

Objective: We aimed to investigate the effects of a one-year low-dose creatine supplementation trial on bone health, lean mass, and muscle function in older postmenopausal women.

Methods: A double-blind, randomized, parallel-group, placebo controlled trial was conducted between November 2011 and November 2013 in Sao Paulo, Brazil. Postmenopausal osteopenic women were randomly allocated (1:1) into creatine (n=56; 1g/d) or placebo group (n=53; dextrose at same dose).