Publications by authors named "Paloma Izquierdo-Castro"
A hallmark of atrial fibrillation is an excess of spontaneous calcium release events, which can be mimicked by β1- or β2-adrenergic stimulation. Because β1-adrenergic receptor blockers (β1-blockers) are primarily used in clinical practice, we here examined the impact of β2-adrenergic stimulation on spontaneous calcium release and assessed whether the R- and S-enantiomers of the non-selective β- blocker carvedilol could reverse these effects. For this purpose, human atrial myocytes were isolated from patients undergoing cardiovascular surgery and subjected to confocal calcium imaging or immunofluorescent labeling of the ryanodine receptor (RyR2).
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- * Results showed that men with AF had a lower L-type calcium current density compared to those without, while women with AF exhibited increased inward currents and more frequent calcium sparks.
- * The findings suggest that calcium regulation issues in AF are influenced by sex, highlighting increased calcium release and electrical activity in women, but decreased calcium current in men.