Publications by authors named "Paloma Contreras"
Objectives: Andean and Tibetan high-altitude natives exhibit a high concentration of nitric oxide (NO) in the lungs, suggesting that NO plays an adaptive role in offsetting hypobaric hypoxia. We examined the exhaled NO concentration as well as partial pressure of several additional high-altitude native populations in order to examine the possibility that this putative adaptive trait, that is, high exhaled NO, is universal.
Methods: We recruited two geographically diverse highland native populations, Tawang Monpa (TM), a Tibetan derived population in North-Eastern India (n = 95, sampled at an altitude of ~3,200 m), and Peruvian Quechua from the highland Andes (n = 412).
Article Synopsis
- Patagonia was one of the last places in the Americas settled by humans around 15,000-20,000 years ago, and there's still a lack of research on the genomic diversity in this region.
- This study analyzes genome data from four modern populations in Central Southern Chile and Patagonia, as well as four ancient individuals from about 1,000 years ago, revealing strong genetic connections between these groups and other Native Americans.
- The findings indicate that the Native Patagonian Kawéskar and Yámana populations have maintained genetic continuity over the last millennium and suggest a historical separation between maritime and terrestrial populations, which later diversified.