Prediction of obeche wood-induced asthma by specific skin prick testing.

Background: It has previously been shown that a positive skin prick test (SPT) result is a good predictor of a positive specific inhalation challenge (SIC) in patients with occupational asthma (OA) related to wheat or rye flours. This association has not been previously studied in OA attributable to obeche wood.

Aims: To describe a clinical series of patients with OA induced by obeche wood.

A functional variant in the serine-threonine kinase coding gene is associated with hypertension: a case-control study in a Finnish population, the Tampere adult population cardiovascular risk study.

Objectives: Hypertension raises the risk of cardiovascular consequences to two-fold or three-fold. The incidence of hypertension is increasing worldwide. Genetic causes of blood pressure are estimated to cause half of the hypertension effect, but the genes behind this are still fairly unclear.

Periodic cohort health examinations in the TAMRISK study show untoward increases in body mass index and blood pressure during 15 years of follow-up.

Background: Obesity is a significant risk factor for hypertension and diabetes. A cohort of 50-year-old voluntary periodic health examination (PHE) participants was analyzed 15 years retrospectively. Our aim was to evaluate changes in body mass index (BMI) and blood pressure in subjects diagnosed with hypertension and/or diabetes in comparison with healthy controls.

Increased alveolar nitric oxide and systemic inflammation markers in silica-exposed workers.

Background: Exposure to silica dust may cause inflammatory responses, primarily in the lungs, although systemic effects have also been reported. Alveolar inflammation can be demonstrated by increased alveolar concentration of nitric oxide (NO), but information on the effects of silica dust on exhaled NO is sparse. Inflammatory mediators including cytokines are known to take part in silica-induced processes, but the role of adipokines has not been studied previously.

Exposure to cobalt in the production of cobalt and cobalt compounds and its effect on the heart.

Aims: To investigate whether exposure to cobalt in cobalt plants has any measurable effect on the cardiovascular system.

Methods: Occupational, cross sectional study, using a self administered questionnaire, blood pressure measurement, electrocardiography, and laboratory tests in which 203 male workers with at least one year of exposure to cobalt and 94 unexposed controls participated. Echocardiography was performed on a subset of 122 most highly exposed cobalt workers, of which 109 were analysed, and on 60 controls, of which 57 were analysed.

Effectiveness of dynamic muscle training, relaxation training, or ordinary activity for chronic neck pain: randomised controlled trial.

Objective: To determine the effectiveness of dynamic muscle training and relaxation training for chronic neck pain.

Design: Randomised controlled trial.

Setting: Five occupational healthcare centres, Tampere, Finland.

Respiratory health of cobalt production workers.

Background: Cobalt production workers are exposed to metallic cobalt and nickel and their compounds and to different irritant gases. The aim of our study was to determine whether long-term exposure is associated with an increased occurrence of respiratory symptoms and findings or diseases, other than asthma, which is a known hazard, among cobalt processing workers.

Methods: The study population was comprised of 110 current and former cobalt workers who had worked more than 10 years in a cobalt plant.

Trends in serum cholesterol and lifestyle indicators in Members of the Finnish Parliament.

Objective: To examine the extent that public health promotion activity is reflected in life styles of national decision makers, by analysing trends in coronary heart disease risk factors in Members of the Finnish Parliament (MPs).

Methods: The MPs were studied at the beginning of two subsequent 4-year parliamentary periods between 1991 and 1999. The studies included analyses of serum total cholesterol and high-density lipoprotein (HDL) cholesterol, and a questionnaire about alcohol, smoking and physical activity.

Respiratory health effects of long-term exposure to different chromium species in stainless steel production.

The aim of this study was to determine whether occupational exposure to chromite, trivalent chromium (Cr(3+)) or hexavalent chromium (Cr(6+)) causes respiratory diseases, an excess of respiratory symptoms, a decrease in pulmonary function or signs of pneumoconiosis among workers in stainless steel production. Altogether, 203 exposed workers and 81 referents with an average employment of 23 years were investigated for indicators of respiratory health on two occasions, in 1993 and in 1998. Data collection with a self-administered questionnaire, flow volume spirometry, measurement of diffusing capacity, chest radiography and laboratory tests were carried out by a mobile research unit.

The effects of asthma on the quality of life and employment of construction workers.

Relatively little is known about the consequences of asthma for patients' work ability. In particular, the relationship between asthma and construction work has not been studied previously. The aim of this study was to determine how asthma affects construction workers' work ability and quality of life, and the most important conditions that cause respiratory symptoms in construction work.