In vitro and in vivo effect of novel GA-CSNPs loaded col-fibrin nanocomposite scaffold on diabetic wound healing.

A non-healing wound is a common problem associated with diabetes mellitus. Chronic inflammation, challenging re-epithelization, unusual growth factors, and impaired angiogenesis are the multifactorial events that contribute to impaired wounds. Hence, in the present work, an innovative GA-CSNPs nanocomposite scaffold has been fabricated by integrating Gallic acid (GA) loaded chitosan nanoparticles (GA-CSNPs) into a genipin crosslinked collagen-fibrin (Col-fibrin) scaffold as wound dressing material.

Fabrication and characterization of Chrysin - A plant polyphenol loaded alginate -chitosan composite for wound healing application.

The present study explores the therapeutic efficacy of sodium alginate-chitosan scaffolds loaded with Chrysin (ALG-CS-CHY) for dermal wound management. Scaffolds were prepared by the vacuum freeze-drying method. The physiochemical characterization was done through Fourier Transform Infra-Red Spectroscopy (FTIR), which revealed the interactions between the scaffold's functional groups and the drug.

Polymeric scaffold of Gallic acid loaded chitosan nanoparticles infused with collagen-fibrin for wound dressing application.

The present study explores the curative efficacy of collagen-fibrin scaffold with Gallic acid loaded Chitosan nanoparticles (GA-CSNPs) in wound healing. GA-CSNPs were synthesized by ionotropic gelation and the incorporation of GA was confirmed with Fourier Transform Infra-Red Spectroscopy (FTIR). Change in the crystal structure of GA was confirmed by X-ray Powder Diffraction (X-PRD) and Differential Scanning Colorimetry (DSC).