Upregulation of Na/H Exchanger in Astrogliosis and Early Alzheimer's Disease Pathogenesis.

Reactive astrogliosis has been indicated as one of the earliest pathological biomarkers in Alzheimer's Disease (AD) pathology. We previously reported that upregulation of the Na/H exchanger isoform 1 (NHE1) protein in reactive astrocytes contributes to neuroinflammation and cognitive function deficits in murine models of ischemic stroke and vascular stenosis. In this study, we utilized AD human post-mortem and APP/PS1dE9 (APP) transgenic mouse brain tissues to determine whether NHE1 upregulation in astrocytes is associated with AD pathogenesis.